Reverse-engineered silk hydrogels for cell and drug delivery

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Silk is an important biopolymer for (bio)medical applications because of its unique and highly versatile structure and its robust clinical track record in human medicine. Silk can be processed into many material formats, including physically and chemically cross-linked hydrogels that have almost limitless applications ranging from tissue engineering to biomedical imaging and sensing. This concise review provides a detailed background of silk hydrogels, including silk structure–function relationships, biocompatibility and biodegradation, and it explores recent developments in silk hydrogel utilization, with specific reference to drug and cell delivery. We address common pitfalls and misconceptions while identifying emerging opportunities, including 3D printing.
LanguageEnglish
Pages469-487
Number of pages19
JournalTherapeutic Delivery
Volume9
Issue number6
DOIs
Publication statusPublished - 3 May 2018

Fingerprint

Hydrogels
Silk
Pharmaceutical Preparations
Biopolymers
Hydrogel
Tissue Engineering
Medicine

Keywords

  • hydrogel
  • self assembly
  • silk fibroin
  • stem cells
  • tissue engineering

Cite this

@article{b5cc687f0d7e4af8904b0c0c51045e36,
title = "Reverse-engineered silk hydrogels for cell and drug delivery",
abstract = "Silk is an important biopolymer for (bio)medical applications because of its unique and highly versatile structure and its robust clinical track record in human medicine. Silk can be processed into many material formats, including physically and chemically cross-linked hydrogels that have almost limitless applications ranging from tissue engineering to biomedical imaging and sensing. This concise review provides a detailed background of silk hydrogels, including silk structure–function relationships, biocompatibility and biodegradation, and it explores recent developments in silk hydrogel utilization, with specific reference to drug and cell delivery. We address common pitfalls and misconceptions while identifying emerging opportunities, including 3D printing.",
keywords = "hydrogel, self assembly, silk fibroin, stem cells, tissue engineering",
author = "Seib, {F Philipp}",
year = "2018",
month = "5",
day = "3",
doi = "10.4155/tde-2018-0016",
language = "English",
volume = "9",
pages = "469--487",
journal = "Therapeutic Delivery",
issn = "2041-5990",
number = "6",

}

Reverse-engineered silk hydrogels for cell and drug delivery. / Seib, F Philipp.

In: Therapeutic Delivery, Vol. 9, No. 6, 03.05.2018, p. 469-487.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reverse-engineered silk hydrogels for cell and drug delivery

AU - Seib, F Philipp

PY - 2018/5/3

Y1 - 2018/5/3

N2 - Silk is an important biopolymer for (bio)medical applications because of its unique and highly versatile structure and its robust clinical track record in human medicine. Silk can be processed into many material formats, including physically and chemically cross-linked hydrogels that have almost limitless applications ranging from tissue engineering to biomedical imaging and sensing. This concise review provides a detailed background of silk hydrogels, including silk structure–function relationships, biocompatibility and biodegradation, and it explores recent developments in silk hydrogel utilization, with specific reference to drug and cell delivery. We address common pitfalls and misconceptions while identifying emerging opportunities, including 3D printing.

AB - Silk is an important biopolymer for (bio)medical applications because of its unique and highly versatile structure and its robust clinical track record in human medicine. Silk can be processed into many material formats, including physically and chemically cross-linked hydrogels that have almost limitless applications ranging from tissue engineering to biomedical imaging and sensing. This concise review provides a detailed background of silk hydrogels, including silk structure–function relationships, biocompatibility and biodegradation, and it explores recent developments in silk hydrogel utilization, with specific reference to drug and cell delivery. We address common pitfalls and misconceptions while identifying emerging opportunities, including 3D printing.

KW - hydrogel

KW - self assembly

KW - silk fibroin

KW - stem cells

KW - tissue engineering

U2 - 10.4155/tde-2018-0016

DO - 10.4155/tde-2018-0016

M3 - Article

VL - 9

SP - 469

EP - 487

JO - Therapeutic Delivery

T2 - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 6

ER -