Abstract
Rett syndrome,' an intellectually
handicapping, probably genetic disorder
affects around one in 10000 females2 and is
remarkable for the absence of coexisting
injury, disease or dysmorphism. As early as
1985, one of us (AMK) observed isolated
shortening of the 4th metatarsal in some
affected girls but not their families.
The British Isles Survey for Rett Syndrome'
and clinics organised by the UK Rett Syndrome
Association have recently provided an
opportunity for serial examinations of cases.
Among the last 50 classic cases aged over 5
years, we have observed nine with this solitary
anomaly (1 in 5-6 cases). It was not observed
in family members. Both feet were usually
affected.
We are now examining residents and staff at
the Royal Scottish National Hospital (Mental
Handicap) as well as further consecutive cases
of Rett syndrome and their families to compare
prevalence in these groups.
Original language | English |
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Pages (from-to) | 433-434 |
Number of pages | 1 |
Journal | Archives of Disease in Childhood |
Volume | 68 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1993 |
Keywords
- Rett syndrome
- 4th metatarsal
- statistics