Retinal representation of the elementary visual signal

Peter H. Li, Greg D. Field, Martin Greschner, Daniel Ahn, Deborah Gunning, Keith Mathieson, Alexander Sher, Alan M. Litke, E.J. Chichilnisky

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong responses with different kinetics in three of the four numerically dominant ganglion cell types. The magnitude and kinetics of light responses in each ganglion cell varied nonlinearly with stimulus strength but in a manner that was independent of the cone of origin after accounting for the overall input strength of each cone. Based on this property of independence, the receptive field profile of an individual ganglion cell could be well estimated from responses to stimulation of each cone individually. Together, these findings provide a quantitative account of how elementary visual inputs form the ganglion cell receptive field. "Visual stimulation was targeted to individual cone photoreceptors in primate retina"Multiple retinal ganglion cell types respond robustly to stimulation of a single cone"Responses in a given ganglion cell are univariant with respect to the cone of origin"Linear approximations of ganglion cell receptive fields predict single-cone responses Li et al. combine targeted visual stimulation of individual cone photoreceptors with simultaneous recording from multiple ganglion cells of identified types in primate retina, providing a quantitative account of how elementary visual inputs form the ganglion cell receptive field.
LanguageEnglish
Pages130-139
Number of pages10
JournalNeuron
Volume81
Issue number1
DOIs
Publication statusPublished - 8 Jan 2014

Fingerprint

visual signals
Ganglia
cones
Retinal Cone Photoreceptor Cells
cells
stimulation
primates
Primates
photoreceptors
Retina
retina
Photic Stimulation
Retinal Ganglion Cells
recording
kinetics
stimuli
Light

Keywords

  • visual signals
  • photoreceptors
  • primate retina

Cite this

Li, PH., Field, GD., Greschner, M., Ahn, D., Gunning, D., Mathieson, K., ... Chichilnisky, E. J. (2014). Retinal representation of the elementary visual signal. Neuron, 81(1), 130-139. https://doi.org/10.1016/j.neuron.2013.10.043
Li, Peter H. ; Field, Greg D. ; Greschner, Martin ; Ahn, Daniel ; Gunning, Deborah ; Mathieson, Keith ; Sher, Alexander ; Litke, Alan M. ; Chichilnisky, E.J. / Retinal representation of the elementary visual signal. In: Neuron. 2014 ; Vol. 81, No. 1. pp. 130-139.
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Li, PH, Field, GD, Greschner, M, Ahn, D, Gunning, D, Mathieson, K, Sher, A, Litke, AM & Chichilnisky, EJ 2014, 'Retinal representation of the elementary visual signal' Neuron, vol. 81, no. 1, pp. 130-139. https://doi.org/10.1016/j.neuron.2013.10.043

Retinal representation of the elementary visual signal. / Li, Peter H.; Field, Greg D.; Greschner, Martin; Ahn, Daniel; Gunning, Deborah; Mathieson, Keith; Sher, Alexander; Litke, Alan M.; Chichilnisky, E.J.

In: Neuron, Vol. 81, No. 1, 08.01.2014, p. 130-139.

Research output: Contribution to journalArticle

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Li PH, Field GD, Greschner M, Ahn D, Gunning D, Mathieson K et al. Retinal representation of the elementary visual signal. Neuron. 2014 Jan 8;81(1):130-139. https://doi.org/10.1016/j.neuron.2013.10.043