Results towards identifiability properties of biochemical reaction networks

M. Farina, R. Findeisen, Eric Bullinger, S. Bittanti, F. Allgöwer, P. Wellstead

Research output: Contribution to conferencePaper

26 Citations (Scopus)

Abstract

In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions on the biochemical reaction network and on the measured outputs that guarantee identifiability of the parameters. Taking the specific system structure of biochemical reaction networks into account, we derive sufficient conditions for local parameter identifiability based on a suitable system expansion which does not any more directly depend on the parameters. Rather, as shown, the problem of identifiability can be recast as the question of observability of the (parameter free) expanded system. The conditions derived are exemplified considering a simple example.
Original languageEnglish
Pages2104-2109
Number of pages6
DOIs
Publication statusPublished - 2006
Event45th IEEE Conference on Decision and Control - San Diego, United States
Duration: 13 Dec 200615 Dec 2006

Conference

Conference45th IEEE Conference on Decision and Control
CountryUnited States
CitySan Diego
Period13/12/0615/12/06

Keywords

  • biochemical reaction networks
  • decision control systems

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