Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men

S.R. Gray, M. Robinson, M.A. Nimmo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 ± 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 ± 8.9 pg ml−1 (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 ± 3.9 ng ml−1 (9.6%) and 37.7 ± 55.6 ng ml−1 (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
LanguageEnglish
Pages247-251
Number of pages4
JournalCell Stress and Chaperones
Volume13
Issue number2
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Cytokine Receptor gp130
Fatigue
Interleukin-6
Fatigue of materials
Exercise
Plasmas
Interleukin-6 Receptors
Lactic Acid
Blood
Exercise Test
Cytokines

Keywords

  • exercise stress
  • interleukin-6
  • receptors
  • fatigue

Cite this

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title = "Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men",
abstract = "The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 ± 6{\%} lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 ± 8.9 pg ml−1 (75.7{\%}) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 ± 3.9 ng ml−1 (9.6{\%}) and 37.7 ± 55.6 ng ml−1 (9.6{\%}), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.",
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Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. / Gray, S.R.; Robinson, M.; Nimmo, M.A.

In: Cell Stress and Chaperones , Vol. 13, No. 2, 06.2008, p. 247-251.

Research output: Contribution to journalArticle

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