Response

Philippe Saiag; Philippe Aegerter; Mathieu Boniol

doi:10.1093/jnci/djw015

Response

Philippe Saiag, Philippe Aegerter, Mathieu Boniol

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

We thank Raimondi et al. for their alternative interpretation of our results on the prognostic value of 25-hydroxyvitamin D3 (25[OH]D3) serum level in melanoma patients. With the observation that standardized value of 25(OH)D3 at diagnosis was not a prognostic factor, our major finding was that a change of 25(OH)D3 serum level upon time in both directions was associated with worse disease-free and overall survivals, with U-shaped curves. We postulated that this latter result was unlikely to be a direct consequence of vitamin D biological actions but rather reflected a global instability in patients’ metabolisms, which finally impact 25(OH)D3 serum level by any …

Original language	English
Article number	djw015
Number of pages	2
Journal	Journal of the National Cancer Institute
Volume	108
Issue number	4
DOIs	https://doi.org/10.1093/jnci/djw015
Publication status	Published - 1 Apr 2016

Keywords

25-hydroxyvitamin D3
melanoma patients
Vitamin D

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jnci/djw015

Saiag-etal-JNCI-2016-ResponseAccepted author manuscript, 371 KB

Cite this

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title = "Response",

abstract = "We thank Raimondi et al. for their alternative interpretation of our results on the prognostic value of 25-hydroxyvitamin D3 (25[OH]D3) serum level in melanoma patients. With the observation that standardized value of 25(OH)D3 at diagnosis was not a prognostic factor, our major finding was that a change of 25(OH)D3 serum level upon time in both directions was associated with worse disease-free and overall survivals, with U-shaped curves. We postulated that this latter result was unlikely to be a direct consequence of vitamin D biological actions but rather reflected a global instability in patients{\textquoteright} metabolisms, which finally impact 25(OH)D3 serum level by any … ",

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AU - Boniol, Mathieu

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AB - We thank Raimondi et al. for their alternative interpretation of our results on the prognostic value of 25-hydroxyvitamin D3 (25[OH]D3) serum level in melanoma patients. With the observation that standardized value of 25(OH)D3 at diagnosis was not a prognostic factor, our major finding was that a change of 25(OH)D3 serum level upon time in both directions was associated with worse disease-free and overall survivals, with U-shaped curves. We postulated that this latter result was unlikely to be a direct consequence of vitamin D biological actions but rather reflected a global instability in patients’ metabolisms, which finally impact 25(OH)D3 serum level by any …

KW - 25-hydroxyvitamin D3

KW - melanoma patients

KW - Vitamin D

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DO - 10.1093/jnci/djw015

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Response

Abstract

Keywords

UN SDGs

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