Philippe Saiag, Philippe Aegerter, Mathieu Boniol

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We thank Raimondi et al. for their alternative interpretation of our results on the prognostic value of 25-hydroxyvitamin D3 (25[OH]D3) serum level in melanoma patients. With the observation that standardized value of 25(OH)D3 at diagnosis was not a prognostic factor, our major finding was that a change of 25(OH)D3 serum level upon time in both directions was associated with worse disease-free and overall survivals, with U-shaped curves. We postulated that this latter result was unlikely to be a direct consequence of vitamin D biological actions but rather reflected a global instability in patients’ metabolisms, which finally impact 25(OH)D3 serum level by any …
Original languageEnglish
Article numberdjw015
Number of pages2
JournalJournal of the National Cancer Institute
Issue number4
Publication statusPublished - 1 Apr 2016


  • 25-hydroxyvitamin D3
  • melanoma patients
  • Vitamin D


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