Resistance by allostery: a novel perspective for Eg5-targeted drug design

AN Viswanath; AN Pae; Simon MacKay

doi:10.1021/jm401071u

Resistance by allostery: a novel perspective for Eg5-targeted drug design

AN Viswanath
, AN Pae
, Simon MacKay

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

Original language	English
Journal	Journal of Medicinal Chemistry
DOIs	https://doi.org/10.1021/jm401071u
Publication status	Published - 2013

Keywords

drug design
allostery

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10.1021/jm401071u

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title = "Resistance by allostery: a novel perspective for Eg5-targeted drug design",

abstract = "Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon {"}resistance by allostery{"}, which could have far-reaching consequences from a rational drug design perspective. ",

keywords = "drug design , allostery",

author = "AN Viswanath and AN Pae and Simon MacKay",

note = "The reference referred to in the abstract has been selected for 'article of the month' by the editor of the journal. This is a commentary on the importance of the original article to drug discovery.",

year = "2013",

doi = "10.1021/jm401071u",

language = "English",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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T1 - Resistance by allostery: a novel perspective for Eg5-targeted drug design

AU - Viswanath, AN

AU - Pae, AN

AU - MacKay, Simon

N1 - The reference referred to in the abstract has been selected for 'article of the month' by the editor of the journal. This is a commentary on the importance of the original article to drug discovery.

PY - 2013

Y1 - 2013

N2 - Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

AB - Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

KW - drug design

KW - allostery

UR - http://pubs.acs.org/doi/abs/10.1021/jm401071u

U2 - 10.1021/jm401071u

DO - 10.1021/jm401071u

M3 - Article

SN - 0022-2623

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

ER -

Resistance by allostery: a novel perspective for Eg5-targeted drug design

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