Resistance by allostery: a novel perspective for Eg5-targeted drug design

AN Viswanath, AN Pae, Simon MacKay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

LanguageEnglish
JournalJournal of Medicinal Chemistry
DOIs
Publication statusPublished - 2013

Fingerprint

Drug Design
SB 743921

Keywords

  • drug design
  • allostery

Cite this

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title = "Resistance by allostery: a novel perspective for Eg5-targeted drug design",
abstract = "Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon {"}resistance by allostery{"}, which could have far-reaching consequences from a rational drug design perspective.",
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publisher = "American Chemical Society",

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Resistance by allostery: a novel perspective for Eg5-targeted drug design. / Viswanath, AN; Pae, AN; MacKay, Simon.

In: Journal of Medicinal Chemistry, 2013.

Research output: Contribution to journalArticle

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AU - Pae, AN

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AB - Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon "resistance by allostery", which could have far-reaching consequences from a rational drug design perspective.

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