Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

Donna Stephanie MacMillan; Jane Murray; Helen F. Sneddon; Craig Jamieson; Allan Watson

doi:10.1039/C2GC36378J

Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

Donna Stephanie MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan Watson

Pure And Applied Chemistry

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Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

Original language	English
Pages (from-to)	3016-3019
Number of pages	4
Journal	Green Chemistry
Volume	14
Issue number	11
Early online date	2 Oct 2012
DOIs	https://doi.org/10.1039/C2GC36378J
Publication status	Published - 2012

Keywords

green chemistry
purification
alternative solvents
chromatography
replacement
dichloromethane
chromatographic purification

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10.1039/C2GC36378J

C2GC36378JFinal published version, 641 KBLicence: Unspecified

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abstract = "Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.",

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AU - Jamieson, Craig

AU - Watson, Allan

PY - 2012

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AB - Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

KW - green chemistry

KW - purification

KW - alternative solvents

KW - chromatography

KW - replacement

KW - dichloromethane

KW - chromatographic purification

U2 - 10.1039/C2GC36378J

DO - 10.1039/C2GC36378J

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JO - Green Chemistry

JF - Green Chemistry

IS - 11

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Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

Abstract

Keywords

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