Replacement of dichloromethane within chromatographic purification

a guide to alternative solvents

Donna Stephanie MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan Watson

Research output: Contribution to journalArticle

32 Citations (Scopus)
386 Downloads (Pure)

Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalGreen Chemistry
Volume14
Issue number11
Early online date2 Oct 2012
DOIs
Publication statusPublished - 2012

Fingerprint

Methylene Chloride
Dichloromethane
Purification
purification
replacement
Molecules
Pharmaceutical Chemistry
programme
analysis

Keywords

  • green chemistry
  • purification
  • alternative solvents
  • chromatography
  • replacement
  • dichloromethane
  • chromatographic purification

Cite this

MacMillan, Donna Stephanie ; Murray, Jane ; Sneddon, Helen F. ; Jamieson, Craig ; Watson, Allan. / Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. In: Green Chemistry. 2012 ; Vol. 14, No. 11. pp. 3016-3019.
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Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents. / MacMillan, Donna Stephanie; Murray, Jane; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan.

In: Green Chemistry, Vol. 14, No. 11, 2012, p. 3016-3019.

Research output: Contribution to journalArticle

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KW - replacement

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