Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

Donna Stephanie MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan Watson

Research output: Contribution to journalArticle

34 Citations (Scopus)
393 Downloads (Pure)

Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalGreen Chemistry
Volume14
Issue number11
Early online date2 Oct 2012
DOIs
Publication statusPublished - 2012

Keywords

  • green chemistry
  • purification
  • alternative solvents
  • chromatography
  • replacement
  • dichloromethane
  • chromatographic purification

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