Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
- green chemistry
- alternative solvents
- chromatographic purification
MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C., & Watson, A. (2012). Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents. Green Chemistry, 14(11), 3016-3019. https://doi.org/10.1039/C2GC36378J