Abstract
| Language | English |
|---|---|
| Pages | 4273-4279 |
| Number of pages | 7 |
| Journal | International Journal of Pharmaceutical Sciences and Research |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 Oct 2018 |
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Keywords
- age
- HIV
- Namibia
- renal function
- TDF
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Renal function outcomes in patients receiving TDF-containing antiretroviral therapy : a retrospective pilot study in Namibia. / Kalemeera, Francis; Oberholster, Carla; Segamwenge, Innocent ; Kibuule, Dan; Naikaku, Ester; Mwangana, M; Godman, Brian.
In: International Journal of Pharmaceutical Sciences and Research, Vol. 9, No. 10, 01.10.2018, p. 4273-4279.Research output: Contribution to journal › Article
TY - JOUR
T1 - Renal function outcomes in patients receiving TDF-containing antiretroviral therapy
T2 - International Journal of Pharmaceutical Sciences and Research
AU - Kalemeera, Francis
AU - Oberholster, Carla
AU - Segamwenge, Innocent
AU - Kibuule, Dan
AU - Naikaku, Ester
AU - Mwangana, M
AU - Godman, Brian
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Introduction and aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implications. Consequently, the aim of this paper is to correct this. Methods: Longitudinal retrospective study, with renal function assessed pre-cART and at various time points on cART using the Cockcroft-Gault method. The data source was the patients’ care booklets. Results: 71 patients were included. The majority were adults and female. Before cART initiation, 70.4% and 29.6% had abnormal and normal CrCl, respectively. CrCl was normalised in 24% of patients, while abnormal in the remainder. The mean (median) time to normalisation was 47.4(33.7) months, observed more in paediatric than adult patients (p =0.014). However, in paediatric patients, normalisation took longer than in adult patients. The reduction in CrCl, was observed at variable time points. 9/16 patients experienced a decline during first-line cART and 7 of these were receiving TDF. 7/16 experienced this during second-line cART and 6 were receiving TDF. Conclusion: HIV is typically the cause of renal impairment prior to cART, with TDF likely to be the cause of renal impairment during cART. Consequently, co-administration of TDF with other nephrotoxic drugs should be undertaken with caution if unavoidable. Overall, improvement in renal impairment was faster in adults.
AB - Introduction and aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implications. Consequently, the aim of this paper is to correct this. Methods: Longitudinal retrospective study, with renal function assessed pre-cART and at various time points on cART using the Cockcroft-Gault method. The data source was the patients’ care booklets. Results: 71 patients were included. The majority were adults and female. Before cART initiation, 70.4% and 29.6% had abnormal and normal CrCl, respectively. CrCl was normalised in 24% of patients, while abnormal in the remainder. The mean (median) time to normalisation was 47.4(33.7) months, observed more in paediatric than adult patients (p =0.014). However, in paediatric patients, normalisation took longer than in adult patients. The reduction in CrCl, was observed at variable time points. 9/16 patients experienced a decline during first-line cART and 7 of these were receiving TDF. 7/16 experienced this during second-line cART and 6 were receiving TDF. Conclusion: HIV is typically the cause of renal impairment prior to cART, with TDF likely to be the cause of renal impairment during cART. Consequently, co-administration of TDF with other nephrotoxic drugs should be undertaken with caution if unavoidable. Overall, improvement in renal impairment was faster in adults.
KW - age
KW - HIV
KW - Namibia
KW - renal function
KW - TDF
UR - http://ijpsr.com/
U2 - 10.13040/IJPSR.0975-8232.9(10).4273-79
DO - 10.13040/IJPSR.0975-8232.9(10).4273-79
M3 - Article
VL - 9
SP - 4273
EP - 4279
JO - International Journal of Pharmaceutical Sciences and Research
JF - International Journal of Pharmaceutical Sciences and Research
SN - 2320-5148
IS - 10
ER -