Projects per year
Abstract
Treating fluorenone or 2-benzoylpyridine with the sodium zincate [(TMEDA)center dot Na(mu-Bu-t)(mu-TMP)Zn(Bu-t)] in hexane solution, gives efficient Bu-t addition across the respective organic substrate in a highly unusual 1,6-fashion, producing isolable organometallic intermediates which can be quenched and aerobically oxidised to give 3-tert-butyl-9H-fluoren-9-one and 2-benzoyl-5-tert-butylpyridine respectively.
Original language | English |
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Pages (from-to) | 3772-3774 |
Number of pages | 3 |
Journal | Chemical Communications (London) |
Volume | 47 |
Issue number | 13 |
DOIs | |
Publication status | Published - 11 Jan 2011 |
Keywords
- metal-mediated zincation
- ferroelectric liquid-crystals
- directed ortho-metalation
- tertiary aromatic amide
- structural insights
- polar order
- 1,4-dihydropyridines
- magnesiation
- derivatives
- complexes
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Dive into the research topics of 'Remote functionalisation via sodium alkylamidozincate intermediates: access to unusual fluorenone and pyridyl ketone reactivity patterns'. Together they form a unique fingerprint.Projects
- 2 Finished
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ENANTIOSELECTIVE APPLICATIONS OF DESIGNER SYNERGIC REAGENTS (First Grant)
O'Hara, C. (Principal Investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/08 → 31/03/12
Project: Research
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Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research