Release of chromium from orthpaedic arthroplasties

G.A. Afolaranmi; J.N.A. Tettey; R.M.D. Meek; M.H. Grant

doi:10.2174/1874325000802010010

Release of chromium from orthpaedic arthroplasties

G.A. Afolaranmi, J.N.A. Tettey, R.M.D. Meek, M.H. Grant

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.

Original language	English
Pages (from-to)	10-18
Number of pages	9
Journal	Open Orthopaedics Journal
Volume	2
Issue number	9
DOIs	https://doi.org/10.2174/1874325000802010010
Publication status	Published - 2008

Keywords

chromium
orthpaedic arthroplasties
bioengineering
orthopaedics

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10.2174/1874325000802010010

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title = "Release of chromium from orthpaedic arthroplasties",

abstract = "Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.",

keywords = "chromium, orthpaedic arthroplasties, bioengineering, orthopaedics",

author = "G.A. Afolaranmi and J.N.A. Tettey and R.M.D. Meek and M.H. Grant",

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AU - Tettey, J.N.A.

AU - Meek, R.M.D.

AU - Grant, M.H.

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N2 - Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.

AB - Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.

KW - chromium

KW - orthpaedic arthroplasties

KW - bioengineering

KW - orthopaedics

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685051/

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JO - Open Orthopaedics Journal

JF - Open Orthopaedics Journal

IS - 9

ER -

Release of chromium from orthpaedic arthroplasties

Abstract

Keywords

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