Release of chromium from orthpaedic arthroplasties

G.A. Afolaranmi, J.N.A. Tettey, R.M.D. Meek, M.H. Grant

Research output: Contribution to journalArticle

Abstract

Many orthopaedic implants are composed of alloys containing chromium. Of particular relevance is the increasing number of Cobalt Chromium bearing arthroplasies being inserted into young patients with osteoarthritis. Such implants will release chromium ions. These patients will be exposed to the released chromium for over 50 years in some cases. The subsequent chromium ion metabolism and redistribution in fluid and tissue compartments is complex. In addition, the potential biological effects of chromium are also controversial, including DNA and chromosomal damage, reduction in CD8 lymphocyte levels and possible hypersensitivity reactions (ALVAL). The establishment of these issues and the measurement of chromium in biological fluids is the subject of this review.
LanguageEnglish
Pages10-18
Number of pages9
JournalOpen Orthopaedics Journal
Volume2
Issue number9
DOIs
Publication statusPublished - 2008

Fingerprint

Arthroplasty
Chromium
Bearings (structural)
Ions
Fluids
Lymphocytes
Orthopedics
Cobalt
Metabolism
Tissue
DNA

Keywords

  • chromium
  • orthpaedic arthroplasties
  • bioengineering
  • orthopaedics

Cite this

Afolaranmi, G. A., Tettey, J. N. A., Meek, R. M. D., & Grant, M. H. (2008). Release of chromium from orthpaedic arthroplasties. Open Orthopaedics Journal, 2(9), 10-18. https://doi.org/10.2174/1874325000802010010
Afolaranmi, G.A. ; Tettey, J.N.A. ; Meek, R.M.D. ; Grant, M.H. / Release of chromium from orthpaedic arthroplasties. In: Open Orthopaedics Journal. 2008 ; Vol. 2, No. 9. pp. 10-18.
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Afolaranmi, GA, Tettey, JNA, Meek, RMD & Grant, MH 2008, 'Release of chromium from orthpaedic arthroplasties' Open Orthopaedics Journal, vol. 2, no. 9, pp. 10-18. https://doi.org/10.2174/1874325000802010010

Release of chromium from orthpaedic arthroplasties. / Afolaranmi, G.A.; Tettey, J.N.A.; Meek, R.M.D.; Grant, M.H.

In: Open Orthopaedics Journal, Vol. 2, No. 9, 2008, p. 10-18.

Research output: Contribution to journalArticle

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