Relationships between radiological and biochemical-evidence of rickets in asian schoolchildren

A.A. Abdul-Motaal, G. Gettinby, W B McIntosh, G R Sutherland, M G Dunnigan

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Abstract

One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population.
Original languageEnglish
Pages (from-to)307-312
Number of pages5
JournalPostgraduate Medical Journal
Volume61
Issue number714
DOIs
Publication statusPublished - 1985

Keywords

  • radiological evidence
  • biochemical-evidence
  • rickets
  • asian schoolchildren
  • vitamin D-deficient

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