Relationship between outdoor temperature and cardiovascular disease risk factors in older people

Claudio Sartini, Sarah J.E. Barry, Peter H. Whincup, S. Goya Wannamethee, Gordon D.O. Lowe, Barbara J. Jefferis, Lucy Lennon, Paul Welsh, Ian Ford, Naveed Sattar, Richard W. Morris

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Previous studies demonstrated that lower outdoor temperatures increase the levels of established cardiovascular disease risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel cardiovascular disease risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel cardiovascular disease risk factors in two large Northern European studies of older adults, in whom cardiovascular disease risk is increased. Design and methods: Data came from the British Regional Heart Study (4252 men aged 60?79 years) and the Prospective Study of Pravastatin in the Elderly at Risk (5804 men and women aged 70?82 years). Associations between outdoor temperature and cardiovascular disease risk factors were quantified in each study and then pooled using a random effects model. Results: With a 5C lower mean temperature, total cholesterol was 0.04 mmol/l (95% confidence interval (CI) 0.02?0.07) higher, low density lipoprotein cholesterol was 0.02 mmol/l (95% CI 0.01?0.05) higher and SBP was 1.12 mm Hg (95% CI 0.60?1.64) higher. Among novel cardiovascular disease risk factors, C-reactive protein was 3.3% (95% CI 1.0?5.6 higher, interleukin-6 was 2.7% (95% CI 1.1?4.3 higher, and vitamin D was 11.2% (95% CI 1.0?20.4 lower. Conclusions: Lower outdoor temperature was associated with adverse effects on cholesterol, blood pressure, circulating inflammatory markers, and vitamin D in two older populations. Public health approaches to protect the elderly against low temperatures could help in reducing the levels of several cardiovascular disease risk factors.
LanguageEnglish
Pages349-356
Number of pages8
JournalEuropean Journal of Preventive Cardiology
Volume24
Issue number4
Early online date29 Nov 2016
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Cardiovascular Diseases
Temperature
Confidence Intervals
Vitamin D
Cholesterol
Blood Pressure
Pravastatin
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Interleukin-6
Public Health
Prospective Studies
Lipids
Population

Keywords

  • biomarkers
  • outdoor temperature
  • older adults
  • cardiovascular disease
  • risk factors

Cite this

Sartini, Claudio ; Barry, Sarah J.E. ; Whincup, Peter H. ; Wannamethee, S. Goya ; Lowe, Gordon D.O. ; Jefferis, Barbara J. ; Lennon, Lucy ; Welsh, Paul ; Ford, Ian ; Sattar, Naveed ; Morris, Richard W. / Relationship between outdoor temperature and cardiovascular disease risk factors in older people. In: European Journal of Preventive Cardiology. 2017 ; Vol. 24, No. 4. pp. 349-356.
@article{17e0d17042e54fc6a1ce83bc8971c11c,
title = "Relationship between outdoor temperature and cardiovascular disease risk factors in older people",
abstract = "Background: Previous studies demonstrated that lower outdoor temperatures increase the levels of established cardiovascular disease risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel cardiovascular disease risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel cardiovascular disease risk factors in two large Northern European studies of older adults, in whom cardiovascular disease risk is increased. Design and methods: Data came from the British Regional Heart Study (4252 men aged 60?79 years) and the Prospective Study of Pravastatin in the Elderly at Risk (5804 men and women aged 70?82 years). Associations between outdoor temperature and cardiovascular disease risk factors were quantified in each study and then pooled using a random effects model. Results: With a 5C lower mean temperature, total cholesterol was 0.04 mmol/l (95{\%} confidence interval (CI) 0.02?0.07) higher, low density lipoprotein cholesterol was 0.02 mmol/l (95{\%} CI 0.01?0.05) higher and SBP was 1.12 mm Hg (95{\%} CI 0.60?1.64) higher. Among novel cardiovascular disease risk factors, C-reactive protein was 3.3{\%} (95{\%} CI 1.0?5.6 higher, interleukin-6 was 2.7{\%} (95{\%} CI 1.1?4.3 higher, and vitamin D was 11.2{\%} (95{\%} CI 1.0?20.4 lower. Conclusions: Lower outdoor temperature was associated with adverse effects on cholesterol, blood pressure, circulating inflammatory markers, and vitamin D in two older populations. Public health approaches to protect the elderly against low temperatures could help in reducing the levels of several cardiovascular disease risk factors.",
keywords = "biomarkers, outdoor temperature, older adults, cardiovascular disease, risk factors",
author = "Claudio Sartini and Barry, {Sarah J.E.} and Whincup, {Peter H.} and Wannamethee, {S. Goya} and Lowe, {Gordon D.O.} and Jefferis, {Barbara J.} and Lucy Lennon and Paul Welsh and Ian Ford and Naveed Sattar and Morris, {Richard W.}",
note = "This research was supported by a British Heart Foundation (BHF) project grant (PG/13/41/30304) which supported CS. The BRHS is supported by a BHF programme grant (RG/13/16/30528).",
year = "2017",
month = "3",
day = "1",
doi = "10.1177/2047487316682119",
language = "English",
volume = "24",
pages = "349--356",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
number = "4",

}

Sartini, C, Barry, SJE, Whincup, PH, Wannamethee, SG, Lowe, GDO, Jefferis, BJ, Lennon, L, Welsh, P, Ford, I, Sattar, N & Morris, RW 2017, 'Relationship between outdoor temperature and cardiovascular disease risk factors in older people' European Journal of Preventive Cardiology, vol. 24, no. 4, pp. 349-356. https://doi.org/10.1177/2047487316682119

Relationship between outdoor temperature and cardiovascular disease risk factors in older people. / Sartini, Claudio; Barry, Sarah J.E.; Whincup, Peter H.; Wannamethee, S. Goya; Lowe, Gordon D.O.; Jefferis, Barbara J.; Lennon, Lucy; Welsh, Paul; Ford, Ian; Sattar, Naveed; Morris, Richard W.

In: European Journal of Preventive Cardiology, Vol. 24, No. 4, 01.03.2017, p. 349-356.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between outdoor temperature and cardiovascular disease risk factors in older people

AU - Sartini, Claudio

AU - Barry, Sarah J.E.

AU - Whincup, Peter H.

AU - Wannamethee, S. Goya

AU - Lowe, Gordon D.O.

AU - Jefferis, Barbara J.

AU - Lennon, Lucy

AU - Welsh, Paul

AU - Ford, Ian

AU - Sattar, Naveed

AU - Morris, Richard W.

N1 - This research was supported by a British Heart Foundation (BHF) project grant (PG/13/41/30304) which supported CS. The BRHS is supported by a BHF programme grant (RG/13/16/30528).

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: Previous studies demonstrated that lower outdoor temperatures increase the levels of established cardiovascular disease risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel cardiovascular disease risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel cardiovascular disease risk factors in two large Northern European studies of older adults, in whom cardiovascular disease risk is increased. Design and methods: Data came from the British Regional Heart Study (4252 men aged 60?79 years) and the Prospective Study of Pravastatin in the Elderly at Risk (5804 men and women aged 70?82 years). Associations between outdoor temperature and cardiovascular disease risk factors were quantified in each study and then pooled using a random effects model. Results: With a 5C lower mean temperature, total cholesterol was 0.04 mmol/l (95% confidence interval (CI) 0.02?0.07) higher, low density lipoprotein cholesterol was 0.02 mmol/l (95% CI 0.01?0.05) higher and SBP was 1.12 mm Hg (95% CI 0.60?1.64) higher. Among novel cardiovascular disease risk factors, C-reactive protein was 3.3% (95% CI 1.0?5.6 higher, interleukin-6 was 2.7% (95% CI 1.1?4.3 higher, and vitamin D was 11.2% (95% CI 1.0?20.4 lower. Conclusions: Lower outdoor temperature was associated with adverse effects on cholesterol, blood pressure, circulating inflammatory markers, and vitamin D in two older populations. Public health approaches to protect the elderly against low temperatures could help in reducing the levels of several cardiovascular disease risk factors.

AB - Background: Previous studies demonstrated that lower outdoor temperatures increase the levels of established cardiovascular disease risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel cardiovascular disease risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel cardiovascular disease risk factors in two large Northern European studies of older adults, in whom cardiovascular disease risk is increased. Design and methods: Data came from the British Regional Heart Study (4252 men aged 60?79 years) and the Prospective Study of Pravastatin in the Elderly at Risk (5804 men and women aged 70?82 years). Associations between outdoor temperature and cardiovascular disease risk factors were quantified in each study and then pooled using a random effects model. Results: With a 5C lower mean temperature, total cholesterol was 0.04 mmol/l (95% confidence interval (CI) 0.02?0.07) higher, low density lipoprotein cholesterol was 0.02 mmol/l (95% CI 0.01?0.05) higher and SBP was 1.12 mm Hg (95% CI 0.60?1.64) higher. Among novel cardiovascular disease risk factors, C-reactive protein was 3.3% (95% CI 1.0?5.6 higher, interleukin-6 was 2.7% (95% CI 1.1?4.3 higher, and vitamin D was 11.2% (95% CI 1.0?20.4 lower. Conclusions: Lower outdoor temperature was associated with adverse effects on cholesterol, blood pressure, circulating inflammatory markers, and vitamin D in two older populations. Public health approaches to protect the elderly against low temperatures could help in reducing the levels of several cardiovascular disease risk factors.

KW - biomarkers

KW - outdoor temperature

KW - older adults

KW - cardiovascular disease

KW - risk factors

U2 - 10.1177/2047487316682119

DO - 10.1177/2047487316682119

M3 - Article

VL - 24

SP - 349

EP - 356

JO - European Journal of Preventive Cardiology

T2 - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 4

ER -