Abstract
| Language | English |
|---|---|
| Pages | 132-141 |
| Number of pages | 10 |
| Journal | Chemosphere |
| Volume | 152 |
| Early online date | 8 Mar 2016 |
| DOIs | |
| Publication status | Published - 1 Jun 2016 |
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Keywords
- antimicrobial resistance
- disinfection
- susceptibility
- drinking water
- drinking water safety
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Relationship between antibiotic- and disinfectant-resistance profiles in bacteria harvested from tap water. / Khan, Sadia; Beattie, Tara K.; Knapp, Charles W.
In: Chemosphere, Vol. 152, 01.06.2016, p. 132-141.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship between antibiotic- and disinfectant-resistance profiles in bacteria harvested from tap water
AU - Khan, Sadia
AU - Beattie, Tara K.
AU - Knapp, Charles W.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Chlorination is commonly used to control levels of bacteria in drinking water; however, viable bacteria may remain due to chlorine resistance. What may be concerning is that surviving bacteria, due to co-selection factors, may also have increased resistance to common antibiotics. This would pose a public health risk as it could link resistant bacteria in the natural environment to human population. Here, we investigated the relationship between chlorine- and antibiotic-resistances by harvesting 148 surviving bacteria from chlorinated drinking-water systems and compared their susceptibilities against chlorine disinfectants and antibiotics. Twenty-two genera were isolated, including members of Paenibacillus, Burkholderia, Escherichia, Sphingomonas and Dermacoccus species. Weak (but significant) correlations were found between chlorine-tolerance and minimum inhibitory concentrations against the antibiotics tetracycline, sulfamethoxazole and amoxicillin, but not against ciprofloxacin; this suggest that chlorine-tolerant bacteria are more likely to also be antibiotic resistant. Further, antibiotic-resistant bacteria survived longer than antibiotic-sensitive organisms when exposed to free chlorine in a contact-time assay; however, there were little differences in susceptibility when exposed to monochloramine. Irrespective of antibiotic-resistance, spore-forming bacteria had higher tolerance against disinfection compounds. The presence of chlorine-resistant bacteria surviving in drinking-water systems may also carry additional risk of antibiotic resistance.
AB - Chlorination is commonly used to control levels of bacteria in drinking water; however, viable bacteria may remain due to chlorine resistance. What may be concerning is that surviving bacteria, due to co-selection factors, may also have increased resistance to common antibiotics. This would pose a public health risk as it could link resistant bacteria in the natural environment to human population. Here, we investigated the relationship between chlorine- and antibiotic-resistances by harvesting 148 surviving bacteria from chlorinated drinking-water systems and compared their susceptibilities against chlorine disinfectants and antibiotics. Twenty-two genera were isolated, including members of Paenibacillus, Burkholderia, Escherichia, Sphingomonas and Dermacoccus species. Weak (but significant) correlations were found between chlorine-tolerance and minimum inhibitory concentrations against the antibiotics tetracycline, sulfamethoxazole and amoxicillin, but not against ciprofloxacin; this suggest that chlorine-tolerant bacteria are more likely to also be antibiotic resistant. Further, antibiotic-resistant bacteria survived longer than antibiotic-sensitive organisms when exposed to free chlorine in a contact-time assay; however, there were little differences in susceptibility when exposed to monochloramine. Irrespective of antibiotic-resistance, spore-forming bacteria had higher tolerance against disinfection compounds. The presence of chlorine-resistant bacteria surviving in drinking-water systems may also carry additional risk of antibiotic resistance.
KW - antimicrobial resistance
KW - disinfection
KW - susceptibility
KW - drinking water
KW - drinking water safety
UR - http://www.sciencedirect.com/science/article/pii/S0045653516302478
U2 - 10.1016/j.chemosphere.2016.02.086
DO - 10.1016/j.chemosphere.2016.02.086
M3 - Article
VL - 152
SP - 132
EP - 141
JO - Chemosphere
T2 - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -