Abstract
Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the risk of breast cancer.
| Language | English |
|---|---|
| Pages | 152-159 |
| Number of pages | 8 |
| Journal | Critical Reviews in Food Science and Nutrition |
| Volume | 56 |
| Issue number | 1 |
| Early online date | 6 Mar 2015 |
| DOIs | |
| Publication status | Published - 2 Jan 2016 |
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Keywords
- hyperinsulinemia
- nutritional epidemiology
- prevention
Cite this
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Relation between breast cancer and high glycemic index or glycemic load : a meta-analysis of prospective cohort studies. / Mullie, Patrick; Koechlin, Alice; Boniol, Mathieu; Autier, Philippe; Boyle, Peter.
In: Critical Reviews in Food Science and Nutrition, Vol. 56, No. 1, 02.01.2016, p. 152-159.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relation between breast cancer and high glycemic index or glycemic load
T2 - Critical Reviews in Food Science and Nutrition
AU - Mullie, Patrick
AU - Koechlin, Alice
AU - Boniol, Mathieu
AU - Autier, Philippe
AU - Boyle, Peter
N1 - This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Food Science and Nutrition on 06/03/2015, available online: http://wwww.tandfonline.com/10.1080/10408398.2012.718723.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the risk of breast cancer.
AB - Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the risk of breast cancer.
KW - hyperinsulinemia
KW - nutritional epidemiology
KW - prevention
UR - http://www.tandfonline.com/doi/full/10.1080/10408398.2012.718723
U2 - 10.1080/10408398.2012.718723
DO - 10.1080/10408398.2012.718723
M3 - Article
VL - 56
SP - 152
EP - 159
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
SN - 1040-8398
IS - 1
ER -