The aerial parts of Goniothalamus gardneri (Annonaceae) has yielded the known flavonoids 2′-hydroxy-4,4′,6′-trimethoxychalcone (flavokawain A), 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone, 4,2′,4′-trihydroxy-6′-methoxydihydrochalcone, 5,7,4′-trimethoxyflavanone (naringenin trimethyl ether) and 7-hydroxy-5,4′-dimethoxyflavanone (tsugafolin) together with three novel compounds, the dimer characterised as (rel)-1β,2α-di-(2,4-dihydroxy-6-methoxybenzoyl)-3β,4α-di-(4-methoxyphenyl)-cyclobutane, 2′,4′-dihydroxy-4,6′-dimethoxychalcone and 2′-hydroxy-4,4′,6′-trimethoxydihydrochalcone. The last two have previously been synthesised but appear to be new natural products. A similar study of the aerial parts of G. thwaitesii led only to the isolation of the known flavonoids myricetin 4′-O-methyl ether-3-O-α-l-rhamnopyranoside (mearnsitrin) and myricetin-3-O-methyl ether (annulatin), together with the triterpenes friedelinol, friedelin and betulinic acid. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data.
- Goniothalamus gardneri
- Goniothalamus thwaitesii
- chalcone dimer
- flavanol glycoside
- flavanol-3-O-methyl ether
- freidelane and lupane triterpenes
Seidel, V., Bailleul, F., & Waterman, P. G. (2000). (Rel)-1β,2α-di-(2,4-dihydroxy-6-methoxybenzoyl)-3β,4α-di-(4-methoxyphenyl)-cyclobutane and other flavonoids form the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii. Phytochemistry, 55(5), 439-446. https://doi.org/10.1016/S0031-9422(00)00346-0