Projects per year
The increase in availability of actinobacterial whole genome sequences has revealed huge numbers of specialised metabolite biosynthetic gene clusters, encoding a range of bioactive molecules such as antibiotics, antifungals, immunosuppressives and anticancer agents. Yet the majority of these clusters are not expressed under standard laboratory conditions in rich media conditions. Emerging data from studies of specialised metabolite biosynthesis suggest that the diversity of regulatory mechanisms is greater than previously thought and these act at multiple levels, through a range of signals such as nutrient limitation, intercellular signalling and competition with other organisms. Understanding the regulation and environmental cues that lead to the production of these compounds allows us to identify the role which these compounds play in their natural habitat as well as providing tools to exploit this untapped source of specialised metabolites for therapeutic uses. Here we provide an overview of novel regulatory mechanisms that act in physiological, global, and cluster specific regulatory manners on biosynthetic pathways in Actinobacteria and consider these alongside their ecological and evolutionary implications.
|Number of pages||21|
|Journal||Environmental Microbiology Reports|
|Early online date||6 Apr 2018|
|Publication status||E-pub ahead of print - 6 Apr 2018|
- gene clusters
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- 2 Finished
Enhancing the yield of industrial Actinomycete fermentations
BBSRC (Biotech & Biological Sciences Research Council)
1/08/16 → 31/07/19
Clash of the Kingdoms: How the quest for nutrients leads to pathogenicity
NERC (Natural Environment Research Council)
31/12/14 → 30/12/17