Regulation and function of uncoordinated-51 like kinase proteins

Edmond Y Chan

Research output: Contribution to journalLiterature review

35 Citations (Scopus)

Abstract

The Atg1/ULK1 (uncoordinated-51 like kinase 1) protein complex plays an essential role regulating autophagy in mammalian cells. As autophagy is implicated in normal cellular homeostasis and multiple diseases, better mechanistic insight drives development of novel therapeutic approaches. RECENT ADVANCES: Multiple independent laboratories have contributed important new insights into the ULK-signalling pathway. ULK1/2 function is regulated by mTOR complex 1 and AMPK through a network of phosphorylation events. ULK signalling controls autophagosome formation in conjunction with other key regulatory factors such as Beclin1 and Atg9.
LanguageEnglish
Pages775-785
Number of pages11
JournalAntioxidants and Redox Signaling
Volume17
Issue number5
DOIs
Publication statusPublished - 1 Sep 2012

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Autophagy
Protein Kinases
Phosphorylation
AMP-Activated Protein Kinases
Homeostasis
Phosphotransferases
Cells
Proteins
Therapeutics
Beclin-1
Autophagosomes

Keywords

  • autophagy
  • signalling pathway network
  • autophagy kinases

Cite this

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Regulation and function of uncoordinated-51 like kinase proteins. / Chan, Edmond Y.

In: Antioxidants and Redox Signaling, Vol. 17, No. 5, 01.09.2012, p. 775-785.

Research output: Contribution to journalLiterature review

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