Regulation and function of uncoordinated-51 like kinase proteins

Edmond Y Chan

Research output: Contribution to journalLiterature review

37 Citations (Scopus)

Abstract

The Atg1/ULK1 (uncoordinated-51 like kinase 1) protein complex plays an essential role regulating autophagy in mammalian cells. As autophagy is implicated in normal cellular homeostasis and multiple diseases, better mechanistic insight drives development of novel therapeutic approaches. RECENT ADVANCES: Multiple independent laboratories have contributed important new insights into the ULK-signalling pathway. ULK1/2 function is regulated by mTOR complex 1 and AMPK through a network of phosphorylation events. ULK signalling controls autophagosome formation in conjunction with other key regulatory factors such as Beclin1 and Atg9.
Original languageEnglish
Pages (from-to)775-785
Number of pages11
JournalAntioxidants and Redox Signaling
Volume17
Issue number5
DOIs
Publication statusPublished - 1 Sep 2012

Keywords

  • autophagy
  • signalling pathway network
  • autophagy kinases

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