Abstract
Treatment of electron deficient pyridine N-oxides with 4-nitrobenzoyl chloride and a cyclic thioether in the presence of triethylamine leads to the corresponding 2-functionalized product in up to 74% iso-lated yield. The transformation can also be accomplished with alternative nitrogen containing hetero-cycles including quinolines, pyrimidines, and pyrazines. To expand the scope of the transformation diisopropyl ether can be used as the reaction medium to allow for the use of solid thioether substrates.
Original language | English |
---|---|
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Early online date | 18 Jan 2018 |
DOIs | |
Publication status | E-pub ahead of print - 18 Jan 2018 |
Keywords
- N-oxides
- heterocycles
- nitrogen