Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations

Benjamin Grant Conway, Elaine Crosbie, Alan Kennedy, Robert E. Mulvey, Stuart D. Robertson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

As the aluminate base [LiAl(TMP)(2)(iBu)(2)] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.

LanguageEnglish
Pages4674-4676
Number of pages3
JournalChemical Communications
Volume48
Issue number39
DOIs
Publication statusPublished - 2012

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Anisoles
Halogenation
Display devices
Thymidine Monophosphate
Halogens

Keywords

  • halogen tolerance
  • heterohalogenation

Cite this

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abstract = "As the aluminate base [LiAl(TMP)(2)(iBu)(2)] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.",
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AU - Mulvey, Robert E.

AU - Robertson, Stuart D.

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