Regional and developmental brain expression patterns of SNAP25 splice variants

Gerald R Prescott, Luke H Chamberlain

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Abstract

SNAP25 is an essential SNARE protein for regulated exocytosis in neuronal cells. Differential splicing of the SNAP25 gene results in the expression of two transcripts, SNAP25a and SNAP25b. These splice variants differ by only 9 amino acids, and studies of their expression to date have been limited to analysis of the corresponding mRNAs. Although these studies have been highly informative, it is possible that factors such as differential turnover of the SNAP25 proteins could complicate interpretations based entirely on mRNA expression profiles.
Original languageEnglish
Article number35
Number of pages9
JournalBMC Neuroscience
Volume12
DOIs
Publication statusPublished - 28 Apr 2011

Keywords

  • SNAP 25
  • SNARE protein
  • brain expression patterns
  • isoforms
  • neuronal cells
  • differential splicing
  • mRNA expression profiles
  • antibodies

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