Refining memory assessment of elderly people with cognitive impairment: insights from the short-term memory binding test

Mario A. Parra, Clara Calia, Ana Frank García, Javier Olazarán-Rodrígue, Juan Antonio Hernandez-Tamames, Juan Alvarez-Linera, Sergio Della Sala, Sara Fernandez Guinea

Research output: Contribution to journalReview article

Abstract

Alzheimer’s disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). We compared data from two studies on temporary binding which assessed people with MCI and controls using different memory loads (2 or 3 items). Selective binding impairments were found in MCI, but relative to controls, such selectivity was contingent upon memory load (i.e., present with 2 items). Further analysis with MCI people who tested positive to neuroimaging biomarkers (i.e., hippocampal atrophy) confirmed that this specific binding impairments are a feature of prodromal AD. The temporary binding task has been recently suggested by consensus papers as a potential screening tool for AD. The results presented here inform on task properties that can maximise the reliability of this new assessment tool for the detection of memory impairments in prodromal cases of AD.
LanguageEnglish
Pages114-120
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume83
Early online date1 Apr 2019
DOIs
Publication statusPublished - 31 Aug 2019

Fingerprint

Short-Term Memory
dementia
Alzheimer Disease
Neuroimaging
Atrophy
Dementia
Consensus
Biomarkers
Cognitive Dysfunction

Keywords

  • short term memory binding
  • mild cognitive impairment
  • prodromal Alzheimer’s disease
  • neuropsychological assessment
  • early detection

Cite this

Parra, M. A., Calia, C., Frank García, A., Olazarán-Rodrígue, J., Hernandez-Tamames, J. A., Alvarez-Linera, J., ... Fernandez Guinea, S. (2019). Refining memory assessment of elderly people with cognitive impairment: insights from the short-term memory binding test. Archives of Gerontology and Geriatrics , 83, 114-120. https://doi.org/10.1016/j.archger.2019.03.025
Parra, Mario A. ; Calia, Clara ; Frank García, Ana ; Olazarán-Rodrígue, Javier ; Hernandez-Tamames, Juan Antonio ; Alvarez-Linera, Juan ; Della Sala, Sergio ; Fernandez Guinea, Sara. / Refining memory assessment of elderly people with cognitive impairment : insights from the short-term memory binding test. In: Archives of Gerontology and Geriatrics . 2019 ; Vol. 83. pp. 114-120.
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Parra, MA, Calia, C, Frank García, A, Olazarán-Rodrígue, J, Hernandez-Tamames, JA, Alvarez-Linera, J, Della Sala, S & Fernandez Guinea, S 2019, 'Refining memory assessment of elderly people with cognitive impairment: insights from the short-term memory binding test' Archives of Gerontology and Geriatrics , vol. 83, pp. 114-120. https://doi.org/10.1016/j.archger.2019.03.025

Refining memory assessment of elderly people with cognitive impairment : insights from the short-term memory binding test. / Parra, Mario A.; Calia, Clara; Frank García, Ana; Olazarán-Rodrígue, Javier; Hernandez-Tamames, Juan Antonio; Alvarez-Linera, Juan; Della Sala, Sergio; Fernandez Guinea, Sara.

In: Archives of Gerontology and Geriatrics , Vol. 83, 31.08.2019, p. 114-120.

Research output: Contribution to journalReview article

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AU - Hernandez-Tamames, Juan Antonio

AU - Alvarez-Linera, Juan

AU - Della Sala, Sergio

AU - Fernandez Guinea, Sara

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