Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients

J.B. Nielsen, J. Brittain, D.M. Halliday, V. Marchand-Pauvert, D. Mazevet, B.A. Conway

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)


    The objective of this study was to use motor unit coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in subjects with stroke. Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke. On the unaffected side, short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. Instead, pronounced 10Hz coupling was observed. It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25Hz frequency band on the affected side in hemiplegic patients during walking.Significance: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration.
    Original languageEnglish
    Pages (from-to)2813-2818
    Number of pages6
    JournalClinical Neurophysiology
    Issue number12
    Publication statusPublished - Dec 2008


    • coherence
    • cross-correlation
    • Motor units
    • Synchronization
    • Walking


    Dive into the research topics of 'Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients'. Together they form a unique fingerprint.

    Cite this