Reducing protein corona formation and enhancing colloidal stability of gold nanoparticles by capping with silica monolayers

Jesús Mosquera, Isabel García, Malou Henriksen-Lacey, Guillermo González-Rubio, Luis M. Liz-Marzán

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalChemistry of Materials
Volume31
Issue number1
Early online date18 Dec 2018
DOIs
Publication statusPublished - 8 Jan 2019

Keywords

  • metal nanoparticales
  • ligands
  • gold
  • silica
  • stability

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