TY - JOUR
T1 - Reducing protein corona formation and enhancing colloidal stability of gold nanoparticles by capping with silica monolayers
AU - Mosquera, Jesús
AU - García, Isabel
AU - Henriksen-Lacey, Malou
AU - González-Rubio, Guillermo
AU - Liz-Marzán, Luis M.
PY - 2019/1/8
Y1 - 2019/1/8
N2 - A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.
AB - A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.
KW - metal nanoparticales
KW - ligands
KW - gold
KW - silica
KW - stability
UR - http://www.scopus.com/inward/record.url?scp=85059680606&partnerID=8YFLogxK
U2 - 10.1021/acs.chemmater.8b04647
DO - 10.1021/acs.chemmater.8b04647
M3 - Article
AN - SCOPUS:85059680606
SN - 0897-4756
VL - 31
SP - 57
EP - 61
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 1
ER -