Red blood cell deformation in flows through a PDMS hyperbolic microchannel

T. Yaginuma, Monica Oliveira, Rui Lima, T. Ishikawa, T. Yamaguchi

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

9 Citations (Scopus)

Abstract

Red blood cells (RBCs) are the major cellular component in blood and are highly deformable in their normal state. RBC deformability is important in the delivery of oxygen to the tissues and plays a major role in microcirculation. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system, namely when there is a change in the cross-sectional area, e.g. in stenoses and in the transition from vessels to catheters (Fujiwara et al. 2009). This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we use microchannels having a hyperbolic shape in which the fluid experiences a nearly constant strain rate at the centerline of the microchannel (Oliveira et al. 2007). The deformation index (DI) measured in these experiments evidences the highly deformable nature of RBCs under strong extensional flows. References Fujiwara, H., et al., 2009, J. Biomech., 42, 838-843. Oliveira, M.S.N., et al., 2007. Exp. Fluids, 43, 437-451.
LanguageEnglish
Title of host publicationProceedings of Microtech Conference & Expo 2011
Subtitle of host publicationTechConnect World 2011
Place of PublicationBoston, Massachusetts
Pages505
Volume2
Publication statusPublished - 14 Jun 2011
EventMicrotech Conference & Expo 2011, TechConnect World 2011 - Boston, Massachusetts, United States
Duration: 14 Jun 201116 Jun 2011

Conference

ConferenceMicrotech Conference & Expo 2011, TechConnect World 2011
CountryUnited States
CityBoston, Massachusetts
Period14/06/1116/06/11

Fingerprint

Microchannels
Blood
Cells
Formability
Microcirculation
Fluids
Catheters
Shear flow
Microfluidics
Strain rate
Tissue
Oxygen
Experiments

Keywords

  • red blood cells
  • deformation
  • extensional flow
  • microfluidics

Cite this

Yaginuma, T., Oliveira, M., Lima, R., Ishikawa, T., & Yamaguchi, T. (2011). Red blood cell deformation in flows through a PDMS hyperbolic microchannel. In Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011 (Vol. 2, pp. 505). Boston, Massachusetts.
Yaginuma, T. ; Oliveira, Monica ; Lima, Rui ; Ishikawa, T. ; Yamaguchi, T. . / Red blood cell deformation in flows through a PDMS hyperbolic microchannel. Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011. Vol. 2 Boston, Massachusetts, 2011. pp. 505
@inbook{d071877bd98d4286b1475c55a6209c62,
title = "Red blood cell deformation in flows through a PDMS hyperbolic microchannel",
abstract = "Red blood cells (RBCs) are the major cellular component in blood and are highly deformable in their normal state. RBC deformability is important in the delivery of oxygen to the tissues and plays a major role in microcirculation. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system, namely when there is a change in the cross-sectional area, e.g. in stenoses and in the transition from vessels to catheters (Fujiwara et al. 2009). This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we use microchannels having a hyperbolic shape in which the fluid experiences a nearly constant strain rate at the centerline of the microchannel (Oliveira et al. 2007). The deformation index (DI) measured in these experiments evidences the highly deformable nature of RBCs under strong extensional flows. References Fujiwara, H., et al., 2009, J. Biomech., 42, 838-843. Oliveira, M.S.N., et al., 2007. Exp. Fluids, 43, 437-451.",
keywords = "red blood cells, deformation, extensional flow, microfluidics",
author = "T. Yaginuma and Monica Oliveira and Rui Lima and T. Ishikawa and T. Yamaguchi",
year = "2011",
month = "6",
day = "14",
language = "English",
volume = "2",
pages = "505",
booktitle = "Proceedings of Microtech Conference & Expo 2011",

}

Yaginuma, T, Oliveira, M, Lima, R, Ishikawa, T & Yamaguchi, T 2011, Red blood cell deformation in flows through a PDMS hyperbolic microchannel. in Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011. vol. 2, Boston, Massachusetts, pp. 505, Microtech Conference & Expo 2011, TechConnect World 2011, Boston, Massachusetts, United States, 14/06/11.

Red blood cell deformation in flows through a PDMS hyperbolic microchannel. / Yaginuma, T.; Oliveira, Monica; Lima, Rui; Ishikawa, T.; Yamaguchi, T. .

Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011. Vol. 2 Boston, Massachusetts, 2011. p. 505.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

TY - CHAP

T1 - Red blood cell deformation in flows through a PDMS hyperbolic microchannel

AU - Yaginuma, T.

AU - Oliveira, Monica

AU - Lima, Rui

AU - Ishikawa, T.

AU - Yamaguchi, T.

PY - 2011/6/14

Y1 - 2011/6/14

N2 - Red blood cells (RBCs) are the major cellular component in blood and are highly deformable in their normal state. RBC deformability is important in the delivery of oxygen to the tissues and plays a major role in microcirculation. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system, namely when there is a change in the cross-sectional area, e.g. in stenoses and in the transition from vessels to catheters (Fujiwara et al. 2009). This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we use microchannels having a hyperbolic shape in which the fluid experiences a nearly constant strain rate at the centerline of the microchannel (Oliveira et al. 2007). The deformation index (DI) measured in these experiments evidences the highly deformable nature of RBCs under strong extensional flows. References Fujiwara, H., et al., 2009, J. Biomech., 42, 838-843. Oliveira, M.S.N., et al., 2007. Exp. Fluids, 43, 437-451.

AB - Red blood cells (RBCs) are the major cellular component in blood and are highly deformable in their normal state. RBC deformability is important in the delivery of oxygen to the tissues and plays a major role in microcirculation. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system, namely when there is a change in the cross-sectional area, e.g. in stenoses and in the transition from vessels to catheters (Fujiwara et al. 2009). This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we use microchannels having a hyperbolic shape in which the fluid experiences a nearly constant strain rate at the centerline of the microchannel (Oliveira et al. 2007). The deformation index (DI) measured in these experiments evidences the highly deformable nature of RBCs under strong extensional flows. References Fujiwara, H., et al., 2009, J. Biomech., 42, 838-843. Oliveira, M.S.N., et al., 2007. Exp. Fluids, 43, 437-451.

KW - red blood cells

KW - deformation

KW - extensional flow

KW - microfluidics

UR - http://www.techconnectworld.com/World2011/a.html?i=1496

M3 - Chapter (peer-reviewed)

VL - 2

SP - 505

BT - Proceedings of Microtech Conference & Expo 2011

CY - Boston, Massachusetts

ER -

Yaginuma T, Oliveira M, Lima R, Ishikawa T, Yamaguchi T. Red blood cell deformation in flows through a PDMS hyperbolic microchannel. In Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011. Vol. 2. Boston, Massachusetts. 2011. p. 505