Red blood cell deformation in flows through a PDMS hyperbolic microchannel

T. Yaginuma, Monica Oliveira, Rui Lima, T. Ishikawa, T. Yamaguchi

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

10 Citations (Scopus)

Abstract

Red blood cells (RBCs) are the major cellular component in blood and are highly deformable in their normal state. RBC deformability is important in the delivery of oxygen to the tissues and plays a major role in microcirculation. Although most studies on RBC deformability consider the effect of shear flow alone, extensionally-dominated flows are often found in the human circulatory system, namely when there is a change in the cross-sectional area, e.g. in stenoses and in the transition from vessels to catheters (Fujiwara et al. 2009). This study aims to characterize the deformation of RBCs in microfluidic extensional flows. For this purpose, we use microchannels having a hyperbolic shape in which the fluid experiences a nearly constant strain rate at the centerline of the microchannel (Oliveira et al. 2007). The deformation index (DI) measured in these experiments evidences the highly deformable nature of RBCs under strong extensional flows. References Fujiwara, H., et al., 2009, J. Biomech., 42, 838-843. Oliveira, M.S.N., et al., 2007. Exp. Fluids, 43, 437-451.
Original languageEnglish
Title of host publicationProceedings of Microtech Conference & Expo 2011
Subtitle of host publicationTechConnect World 2011
Place of PublicationBoston, Massachusetts
Pages505
Volume2
Publication statusPublished - 14 Jun 2011
EventMicrotech Conference & Expo 2011, TechConnect World 2011 - Boston, Massachusetts, United States
Duration: 14 Jun 201116 Jun 2011

Conference

ConferenceMicrotech Conference & Expo 2011, TechConnect World 2011
CountryUnited States
CityBoston, Massachusetts
Period14/06/1116/06/11

Keywords

  • red blood cells
  • deformation
  • extensional flow
  • microfluidics

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    Yaginuma, T., Oliveira, M., Lima, R., Ishikawa, T., & Yamaguchi, T. (2011). Red blood cell deformation in flows through a PDMS hyperbolic microchannel. In Proceedings of Microtech Conference & Expo 2011: TechConnect World 2011 (Vol. 2, pp. 505). Boston, Massachusetts.