Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes

William J. Kerr, Marek Pazicky, Duncan. McArthur

Research output: Contribution to conferenceOther

Abstract

In 2000, our group reported on the first examples of successful deprotonations of 4-substituted cyclohexanones, using simple magnesium amide base chem., with the com. available chiral amine (R)-(+)-N-benzyl-a-methylbenzylamine. Further applications to asym. deprotonation reactions with alternative chiral base species have now been developed. In particular, new supported C2-sym. magnesium amide bases have been established. In turn, novel sol. and insol. polymers have been applied to the asym. deprotonation reaction of prochiral ketones with superb selectivity (Scheme 1). Furthermore, a supported base recycling protocol has also been developed. [on SciFinder(R)]
Original languageUndefined/Unknown
PagesORGN-045
Publication statusPublished - 2008
EventAsymmetric Reactions and Syntheses - Pennsylvania, United States
Duration: 17 Aug 2008 → …

Conference

ConferenceAsymmetric Reactions and Syntheses
CountryUnited States
CityPennsylvania
Period17/08/08 → …

Keywords

  • chiral amines
  • asymmetric Mg-amide base processes

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