Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes

William J. Kerr, Marek Pazicky, Duncan. McArthur

Research output: Contribution to conferenceOther

Abstract

In 2000, our group reported on the first examples of successful deprotonations of 4-substituted cyclohexanones, using simple magnesium amide base chem., with the com. available chiral amine (R)-(+)-N-benzyl-a-methylbenzylamine. Further applications to asym. deprotonation reactions with alternative chiral base species have now been developed. In particular, new supported C2-sym. magnesium amide bases have been established. In turn, novel sol. and insol. polymers have been applied to the asym. deprotonation reaction of prochiral ketones with superb selectivity (Scheme 1). Furthermore, a supported base recycling protocol has also been developed. [on SciFinder(R)]
LanguageUndefined/Unknown
PagesORGN-045
Publication statusPublished - 2008
EventAsymmetric Reactions and Syntheses - Pennsylvania, United States
Duration: 17 Aug 2008 → …

Conference

ConferenceAsymmetric Reactions and Syntheses
CountryUnited States
CityPennsylvania
Period17/08/08 → …

Keywords

  • chiral amines
  • asymmetric Mg-amide base processes

Cite this

Kerr, W. J., Pazicky, M., & McArthur, D. (2008). Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes. ORGN-045. Asymmetric Reactions and Syntheses, Pennsylvania, United States.
Kerr, William J. ; Pazicky, Marek ; McArthur, Duncan. / Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes. Asymmetric Reactions and Syntheses, Pennsylvania, United States.
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abstract = "In 2000, our group reported on the first examples of successful deprotonations of 4-substituted cyclohexanones, using simple magnesium amide base chem., with the com. available chiral amine (R)-(+)-N-benzyl-a-methylbenzylamine. Further applications to asym. deprotonation reactions with alternative chiral base species have now been developed. In particular, new supported C2-sym. magnesium amide bases have been established. In turn, novel sol. and insol. polymers have been applied to the asym. deprotonation reaction of prochiral ketones with superb selectivity (Scheme 1). Furthermore, a supported base recycling protocol has also been developed. [on SciFinder(R)]",
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Kerr, WJ, Pazicky, M & McArthur, D 2008, 'Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes' Asymmetric Reactions and Syntheses, Pennsylvania, United States, 17/08/08, pp. ORGN-045.

Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes. / Kerr, William J.; Pazicky, Marek; McArthur, Duncan.

2008. ORGN-045 Asymmetric Reactions and Syntheses, Pennsylvania, United States.

Research output: Contribution to conferenceOther

TY - CONF

T1 - Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes

AU - Kerr, William J.

AU - Pazicky, Marek

AU - McArthur, Duncan.

PY - 2008

Y1 - 2008

N2 - In 2000, our group reported on the first examples of successful deprotonations of 4-substituted cyclohexanones, using simple magnesium amide base chem., with the com. available chiral amine (R)-(+)-N-benzyl-a-methylbenzylamine. Further applications to asym. deprotonation reactions with alternative chiral base species have now been developed. In particular, new supported C2-sym. magnesium amide bases have been established. In turn, novel sol. and insol. polymers have been applied to the asym. deprotonation reaction of prochiral ketones with superb selectivity (Scheme 1). Furthermore, a supported base recycling protocol has also been developed. [on SciFinder(R)]

AB - In 2000, our group reported on the first examples of successful deprotonations of 4-substituted cyclohexanones, using simple magnesium amide base chem., with the com. available chiral amine (R)-(+)-N-benzyl-a-methylbenzylamine. Further applications to asym. deprotonation reactions with alternative chiral base species have now been developed. In particular, new supported C2-sym. magnesium amide bases have been established. In turn, novel sol. and insol. polymers have been applied to the asym. deprotonation reaction of prochiral ketones with superb selectivity (Scheme 1). Furthermore, a supported base recycling protocol has also been developed. [on SciFinder(R)]

KW - chiral amines

KW - asymmetric Mg-amide base processes

UR - http://oasys2.confex.com/acs/236nm/techprogram/P1173516.HTM

M3 - Other

SP - ORGN-045

ER -

Kerr WJ, Pazicky M, McArthur D. Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes. 2008. Asymmetric Reactions and Syntheses, Pennsylvania, United States.