Projects per year
Abstract
INTRODUCTION: At the time of diagnosis, more than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus (DM). In individuals aged >50 years with DM of <1 year duration, the relative risk of PDAC increases 6-8 fold. New Onset DM (NOD) is thus an early warning sign of PDAC and represents the largest high-risk group for PDAC. To discover biomarkers and develop a targeted screening programme in this population, the establishment of representative, prospective, well characterised cohorts are needed.
AIMS: UK-EDI is a Cancer Research UK-funded study that aims to develop a diagnostic test for use in individuals with NOD to identify those most at risk of a diagnosis of PDAC, allowing them to be screened. To do this, a well characterised cohort of 2,500 individuals with NOD will be recruited, and associated biospecimens and clinical data collected.
MATERIALS AND METHODS: Recruitment pathways spanning the primary and secondary care interface to identify individuals representative of NOD within the population have been developed.
RESULTS: Secondary care sites identify individuals presenting via emergency admission areas screened for hyperglycaemia and DM is subsequently confirmed with HbA1c. Primary care centres refer individuals with NOD to the nearest secondary care site after screening local electronic records for eligible participants. Biospecimens and clinical data are collected every 6 months over a 24-month follow-up period.
CONCLUSION: UK-EDI will develop a bespoke cohort of individuals with NOD, with biospecimens and clinical data annotated, to allow the development of targeted screening for the future early detection of PDAC.
Original language | English |
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Article number | P.248 |
Pages (from-to) | S109 |
Number of pages | 1 |
Journal | Pancreatology |
Volume | 21 |
Issue number | Supplement 1 |
DOIs | |
Publication status | Published - 1 Jul 2021 |
Event | European Pancreatic Club: 53rd Meeting - Virtual Congress, Verona, Italy Duration: 9 Jun 2021 → 11 Jun 2021 https://epc2021.com/wordpress/wp-content/uploads/EPC2021_posters0906.pdf |
Keywords
- pancreatic cancer
- early detection
- patient recruitment
- PDAC
- new onset diabetes mellitus
- biomarker
- screening
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Detecting pancreatic cancer in the largest high-risk group for this disease: A top-down approach (CRUK Early Detection Programme)
van der Meer, R. (Principal Investigator) & Morton, A. (Co-investigator)
1/04/19 → 30/06/25
Project: Research
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ADEPTS: Accelerated Diagnosis of neuroEndocrine and Pancreatic TumourS
van der Meer, R. (Principal Investigator) & Morton, A. (Co-investigator)
1/11/18 → 31/10/22
Project: Research
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Cost-benefit analysis of biomarker-driven early detection of pancreatic cancer in individuals with new-onset diabetes
Stefanova, I., Thompson, N., Stott, M., Oldfield, L., Hanson, R., van der Meer, R., Palmer, D., Greenhalf, W., Halloran, C. & Costello, E., 27 Jun 2024. 1 p.Research output: Contribution to conference › Poster › peer-review
Open AccessFile -
Downstaging the most deadly cancer is cost-effective. Can we achieve a cost-effective early diagnosis?
Zamora, B., Ney, A., van der Meer, R., Thompson, N., Pereira, S. & Ni, M., 2 Dec 2022. 1 p.Research output: Contribution to conference › Abstract › peer-review
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United Kingdom Early Detection Initiative (UK-EDI): protocol for establishing a national multicentre cohort of individuals with new-onset diabetes for early detection of pancreatic cancer
Oldfield, L., Stott, M., Hanson, R., Jackson, R. J., Reynolds, W., Chandran-Gorner, V., Van Der Meer, R., Alison, L., Tejeiro, R., Purewal, T., Ghaneh, P., Palmer, D., Greenhalf, W., Halloran, C. & Costello, E., 10 Oct 2022, In: BMJ open. 12, 10, e068010.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)26 Downloads (Pure)
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Cost-effectiveness & socio-economic implications of screening individuals with new onset diabetes for pancreatic cancer
van der Meer, R. (Speaker)
20 Nov 2019Activity: Talk or presentation types › Invited talk
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Interview on STV News on early diagnosis of pancreatic cancer
van der Meer, R. (Interviewee) & McKay, C. J. (Interviewee)
1 May 2019Activity: Public Engagement and Outreach › Media Participation
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Meeting of Scientific Advisory Board of Pancreatic Cancer UK and Launch of the ADEPTS study
Pereira, S. (Invited speaker), Hippisley-Cox, J. (Invited speaker), Hsuan, J. (Invited speaker), Timms, J. (Invited speaker), Braconi, C. (Invited speaker), van der Meer, R. (Invited speaker) & Zhifang Ni, M. (Invited speaker)
26 Jun 2018 → 27 Jun 2018Activity: Participating in or organising an event types › Participation in workshop, seminar, course