Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

Gergely Simon; Jose Marques-Hueso; Marc P. Y. Desmulliez; Anne L. Bernassau; D. Roolvink; G. Burns; P. A. G. Cormack; Marco A. B. Andrade; Julien Reboud; Jonathan M. Cooper; Mathis O. Riehle

Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

Gergely Simon, Jose Marques-Hueso, Marc P. Y. Desmulliez, Anne L. Bernassau, D. Roolvink, G. Burns, P. A. G. Cormack, Marco A. B. Andrade, Julien Reboud, Jonathan M. Cooper, Mathis O. Riehle

Pure And Applied Chemistry

Research output: Contribution to conference › Paper › peer-review

2 Citations (Scopus)

69 Downloads (Pure)

Abstract

Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

Original language	English
Number of pages	7
Publication status	Published - 23 Jul 2017
Event	24th International Conference on Sound and Vibration - London, United Kingdom Duration: 23 Jul 2017 → 27 Jul 2017

Conference

Conference	24th International Conference on Sound and Vibration
Abbreviated title	ICSV24
Country/Territory	United Kingdom
City	London
Period	23/07/17 → 27/07/17

Keywords

acoustic radiation force
cell sorting
stem cell technologies
micro-particles

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title = "Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices",

abstract = "Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.",

keywords = "acoustic radiation force, cell sorting, stem cell technologies, micro-particles",

author = "Gergely Simon and Jose Marques-Hueso and Desmulliez, {Marc P. Y.} and Bernassau, {Anne L.} and D. Roolvink and G. Burns and Cormack, {P. A. G.} and Andrade, {Marco A. B.} and Julien Reboud and Cooper, {Jonathan M.} and Riehle, {Mathis O.}",

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note = "24th International Conference on Sound and Vibration, ICSV24 ; Conference date: 23-07-2017 Through 27-07-2017",

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T1 - Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

AU - Simon, Gergely

AU - Marques-Hueso, Jose

AU - Desmulliez, Marc P. Y.

AU - Bernassau, Anne L.

AU - Roolvink, D.

AU - Burns, G.

AU - Cormack, P. A. G.

AU - Andrade, Marco A. B.

AU - Reboud, Julien

AU - Cooper, Jonathan M.

AU - Riehle, Mathis O.

PY - 2017/7/23

Y1 - 2017/7/23

N2 - Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

AB - Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

KW - acoustic radiation force

KW - cell sorting

KW - stem cell technologies

KW - micro-particles

M3 - Paper

T2 - 24th International Conference on Sound and Vibration

Y2 - 23 July 2017 through 27 July 2017

ER -

Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

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Conference

Keywords

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