Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.
|Number of pages||7|
|Publication status||Published - 23 Jul 2017|
|Event||24th International Conference on Sound and Vibration - London, United Kingdom|
Duration: 23 Jul 2017 → 27 Jul 2017
|Conference||24th International Conference on Sound and Vibration|
|Period||23/07/17 → 27/07/17|
- acoustic radiation force
- cell sorting
- stem cell technologies
Simon, G., Marques-Hueso, J., Desmulliez, M. P. Y., Bernassau, A. L., Roolvink, D., Burns, G., ... Riehle, M. O. (2017). Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.