Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

Gergely Simon, Jose Marques-Hueso, Marc P. Y. Desmulliez, Anne L. Bernassau, D. Roolvink, G. Burns, P. A. G. Cormack, Marco A. B. Andrade, Julien Reboud, Jonathan M. Cooper, Mathis O. Riehle

Research output: Contribution to conferencePaper

Abstract

Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.
LanguageEnglish
Number of pages7
Publication statusPublished - 23 Jul 2017
Event24th International Conference on Sound and Vibration - London, United Kingdom
Duration: 23 Jul 201727 Jul 2017

Conference

Conference24th International Conference on Sound and Vibration
Abbreviated titleICSV24
CountryUnited Kingdom
CityLondon
Period23/07/1727/07/17

Fingerprint

Acoustic fields
Microfluidics
Acoustics
Stem cells
Tissue engineering
Labels
Recovery

Keywords

  • acoustic radiation force
  • cell sorting
  • stem cell technologies
  • micro-particles

Cite this

Simon, G., Marques-Hueso, J., Desmulliez, M. P. Y., Bernassau, A. L., Roolvink, D., Burns, G., ... Riehle, M. O. (2017). Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.
Simon, Gergely ; Marques-Hueso, Jose ; Desmulliez, Marc P. Y. ; Bernassau, Anne L. ; Roolvink, D. ; Burns, G. ; Cormack, P. A. G. ; Andrade, Marco A. B. ; Reboud, Julien ; Cooper, Jonathan M. ; Riehle, Mathis O. / Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.7 p.
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title = "Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices",
abstract = "Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100{\%}.",
keywords = "acoustic radiation force, cell sorting, stem cell technologies, micro-particles",
author = "Gergely Simon and Jose Marques-Hueso and Desmulliez, {Marc P. Y.} and Bernassau, {Anne L.} and D. Roolvink and G. Burns and Cormack, {P. A. G.} and Andrade, {Marco A. B.} and Julien Reboud and Cooper, {Jonathan M.} and Riehle, {Mathis O.}",
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note = "24th International Conference on Sound and Vibration, ICSV24 ; Conference date: 23-07-2017 Through 27-07-2017",

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Simon, G, Marques-Hueso, J, Desmulliez, MPY, Bernassau, AL, Roolvink, D, Burns, G, Cormack, PAG, Andrade, MAB, Reboud, J, Cooper, JM & Riehle, MO 2017, 'Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices' Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom, 23/07/17 - 27/07/17, .

Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. / Simon, Gergely; Marques-Hueso, Jose; Desmulliez, Marc P. Y.; Bernassau, Anne L.; Roolvink, D.; Burns, G.; Cormack, P. A. G.; Andrade, Marco A. B.; Reboud, Julien; Cooper, Jonathan M.; Riehle, Mathis O.

2017. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

AU - Simon, Gergely

AU - Marques-Hueso, Jose

AU - Desmulliez, Marc P. Y.

AU - Bernassau, Anne L.

AU - Roolvink, D.

AU - Burns, G.

AU - Cormack, P. A. G.

AU - Andrade, Marco A. B.

AU - Reboud, Julien

AU - Cooper, Jonathan M.

AU - Riehle, Mathis O.

PY - 2017/7/23

Y1 - 2017/7/23

N2 - Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

AB - Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.

KW - acoustic radiation force

KW - cell sorting

KW - stem cell technologies

KW - micro-particles

M3 - Paper

ER -

Simon G, Marques-Hueso J, Desmulliez MPY, Bernassau AL, Roolvink D, Burns G et al. Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. 2017. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.