Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices

Gergely Simon, Jose Marques-Hueso, Marc P. Y. Desmulliez, Anne L. Bernassau, D. Roolvink, G. Burns, P. A. G. Cormack, Marco A. B. Andrade, Julien Reboud, Jonathan M. Cooper, Mathis O. Riehle

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Abstract

Advances in diagnostics, cell and stem cell technologies drive the development of application specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for label-free, high recovery, cell and particle separation and isolation in tissue engineering and targeted drug delivery. In this paper, we present two methods of separating particles in a microfluidic channel. The first method uses custom-made micro-particles and by changing the acoustic contrast factor, the micro-particles shift from acoustic node to antinodes, compared to commercialised micro-particles. The second method relies on shifting the acoustic standing wave in a pattern called dynamic acoustic field. We demonstrate that both methods separate particles up to 100%.
Original languageEnglish
Number of pages7
Publication statusPublished - 23 Jul 2017
Event24th International Conference on Sound and Vibration - London, United Kingdom
Duration: 23 Jul 201727 Jul 2017

Conference

Conference24th International Conference on Sound and Vibration
Abbreviated titleICSV24
CountryUnited Kingdom
CityLondon
Period23/07/1727/07/17

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Keywords

  • acoustic radiation force
  • cell sorting
  • stem cell technologies
  • micro-particles

Cite this

Simon, G., Marques-Hueso, J., Desmulliez, M. P. Y., Bernassau, A. L., Roolvink, D., Burns, G., ... Riehle, M. O. (2017). Reconfigurable particle separation by dynamic acoustic fields in microfluidic devices. Paper presented at 24th International Conference on Sound and Vibration, London, United Kingdom.