Recent developments in organoboron chemistry - old dogs, new tricks

James W.B. Fyfe, Allan J.B. Watson

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Organoboron reagents have been synonymous with organic chemistry for over half a century and continue to see widespread application today; for example, classic reactions such as hydroboration and Suzuki-Miyaura cross-coupling are regularly practiced throughout the chemical community. In particular, applications of organoboron compounds have underpinned pharmaceutical and agrochemical development on both discovery and process scales for decades. Although it is noteworthy that these seminal reactions have stood the test of time, continually increasing pressure to improve efficiency in chemical synthesis demands innovation. Over the past few years, through an explosion in the number of new methods for the installation and manipulation of organoboron functional groups, as well as the understanding of their mechanistic operation, organoboron chemistry has risen to this challenge.
LanguageEnglish
Pages31-35
Number of pages5
JournalChem
Volume3
Issue number1
DOIs
Publication statusPublished - 13 Jul 2017

Fingerprint

Organic Chemistry
Agrochemicals
Explosions
Pressure
agrochemical
Pharmaceutical Preparations
Drug products
Functional groups
functional group
explosion
drug
innovation
Innovation
chemical
dog
organic chemistry
demand
method
test

Keywords

  • organoboron reagents
  • organic chemistry
  • organic synthesis

Cite this

Fyfe, James W.B. ; Watson, Allan J.B. / Recent developments in organoboron chemistry - old dogs, new tricks. In: Chem. 2017 ; Vol. 3, No. 1. pp. 31-35.
@article{90875ca707414e08859dd9364b73967c,
title = "Recent developments in organoboron chemistry - old dogs, new tricks",
abstract = "Organoboron reagents have been synonymous with organic chemistry for over half a century and continue to see widespread application today; for example, classic reactions such as hydroboration and Suzuki-Miyaura cross-coupling are regularly practiced throughout the chemical community. In particular, applications of organoboron compounds have underpinned pharmaceutical and agrochemical development on both discovery and process scales for decades. Although it is noteworthy that these seminal reactions have stood the test of time, continually increasing pressure to improve efficiency in chemical synthesis demands innovation. Over the past few years, through an explosion in the number of new methods for the installation and manipulation of organoboron functional groups, as well as the understanding of their mechanistic operation, organoboron chemistry has risen to this challenge.",
keywords = "organoboron reagents, organic chemistry, organic synthesis",
author = "Fyfe, {James W.B.} and Watson, {Allan J.B.}",
year = "2017",
month = "7",
day = "13",
doi = "10.1016/j.chempr.2017.05.008",
language = "English",
volume = "3",
pages = "31--35",
journal = "Chem",
issn = "2451-9294",
number = "1",

}

Recent developments in organoboron chemistry - old dogs, new tricks. / Fyfe, James W.B.; Watson, Allan J.B.

In: Chem, Vol. 3, No. 1, 13.07.2017, p. 31-35.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Recent developments in organoboron chemistry - old dogs, new tricks

AU - Fyfe, James W.B.

AU - Watson, Allan J.B.

PY - 2017/7/13

Y1 - 2017/7/13

N2 - Organoboron reagents have been synonymous with organic chemistry for over half a century and continue to see widespread application today; for example, classic reactions such as hydroboration and Suzuki-Miyaura cross-coupling are regularly practiced throughout the chemical community. In particular, applications of organoboron compounds have underpinned pharmaceutical and agrochemical development on both discovery and process scales for decades. Although it is noteworthy that these seminal reactions have stood the test of time, continually increasing pressure to improve efficiency in chemical synthesis demands innovation. Over the past few years, through an explosion in the number of new methods for the installation and manipulation of organoboron functional groups, as well as the understanding of their mechanistic operation, organoboron chemistry has risen to this challenge.

AB - Organoboron reagents have been synonymous with organic chemistry for over half a century and continue to see widespread application today; for example, classic reactions such as hydroboration and Suzuki-Miyaura cross-coupling are regularly practiced throughout the chemical community. In particular, applications of organoboron compounds have underpinned pharmaceutical and agrochemical development on both discovery and process scales for decades. Although it is noteworthy that these seminal reactions have stood the test of time, continually increasing pressure to improve efficiency in chemical synthesis demands innovation. Over the past few years, through an explosion in the number of new methods for the installation and manipulation of organoboron functional groups, as well as the understanding of their mechanistic operation, organoboron chemistry has risen to this challenge.

KW - organoboron reagents

KW - organic chemistry

KW - organic synthesis

UR - http://www.sciencedirect.com/science/article/pii/S2451929417302218

U2 - 10.1016/j.chempr.2017.05.008

DO - 10.1016/j.chempr.2017.05.008

M3 - Review article

VL - 3

SP - 31

EP - 35

JO - Chem

T2 - Chem

JF - Chem

SN - 2451-9294

IS - 1

ER -