Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview

Manasik Gumah Ali, Zhening Zhang, Qi Gao, Mingzhu Pan, Edward G. Rowan, Juan Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Antibodies are considered as an excellent foundation to neutralize pathogens and as highly specific therapeutic agents. Antibodies are generated in response to a vaccine but little use as immunotherapy to combat virus infections. A new generation of broadly cross-reactive and highly potent antibodies has led to a unique chance for them to be used as a medical intervention. Neutralizing antibodies (monoclonal and polyclonal antibodies) are desirable for pharmaceutical products because of their ability to target specific epitopes with their variable domains by precise neutralization mechanisms. The isolation of neutralizing antiviral antibodies has been achieved by Phage displayed antibody libraries, transgenic mice, B cell approaches, and hybridoma technology. Antibody engineering technologies have led to efficacy improvements, to further boost antibody in vivo activities. “Although neutralizing antiviral antibodies have some limitations that hinder their full development as therapeutic agents, the potential for prevention and treatment of infections, including a range of viruses (HIV, Ebola, MERS-COV, CHIKV, SARS-CoV, and SARS-CoV2), are being actively pursued in human clinical trials.”.

Original languageEnglish
Pages (from-to)325-339
Number of pages15
JournalImmunologic Research
Volume68
Issue number6
Early online date8 Nov 2020
DOIs
Publication statusPublished - 31 Dec 2020

Keywords

  • epitope
  • glycoprotein
  • humoral immune response
  • monoclonal
  • neutralizing antibodies
  • phage display
  • polyclonal

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