Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia

Mario Amore Cecchini, Mônica Sanches Yassuda, Valéria Santoro Bahia, Leonardo Cruz de Souza, Henrique Cerqueira Guimarães, Paulo Caramelli, Maria Teresa Carthery-Goulart, Flávia Patrocínio, Maria Paula Foss, Vitor Tumas, Thaís Bento Lima-Silva, Sônia Maria Dozzi Brucki, Ricardo Nitrini, Sergio Della Sala, Mario A. Parra

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.

LanguageEnglish
Pages2162-2169
Number of pages8
JournalJournal of Neurology
Volume264
Issue number10
Early online date11 Sep 2017
DOIs
Publication statusPublished - 31 Oct 2017

Fingerprint

Frontotemporal Dementia
Alzheimer Disease
Short-Term Memory
Area Under Curve
Sensitivity and Specificity
Aptitude
ROC Curve
Dementia
Differential Diagnosis
Color
Biomarkers

Keywords

  • frontotemporal dementia
  • Alzheimer disease
  • memory disorders

Cite this

Cecchini, M. A., Yassuda, M. S., Bahia, V. S., de Souza, L. C., Guimarães, H. C., Caramelli, P., ... Parra, M. A. (2017). Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia. Journal of Neurology, 264(10), 2162-2169. https://doi.org/10.1007/s00415-017-8614-9
Cecchini, Mario Amore ; Yassuda, Mônica Sanches ; Bahia, Valéria Santoro ; de Souza, Leonardo Cruz ; Guimarães, Henrique Cerqueira ; Caramelli, Paulo ; Carthery-Goulart, Maria Teresa ; Patrocínio, Flávia ; Foss, Maria Paula ; Tumas, Vitor ; Lima-Silva, Thaís Bento ; Brucki, Sônia Maria Dozzi ; Nitrini, Ricardo ; Della Sala, Sergio ; Parra, Mario A. / Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia. In: Journal of Neurology. 2017 ; Vol. 264, No. 10. pp. 2162-2169.
@article{433e8b7513994673b7da560adf3fcd9d,
title = "Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia",
abstract = "It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4{\%} of sensitivity and 80{\%} of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2{\%} of sensitivity and 80{\%} of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.",
keywords = "frontotemporal dementia, Alzheimer disease, memory disorders",
author = "Cecchini, {Mario Amore} and Yassuda, {M{\^o}nica Sanches} and Bahia, {Val{\'e}ria Santoro} and {de Souza}, {Leonardo Cruz} and Guimar{\~a}es, {Henrique Cerqueira} and Paulo Caramelli and Carthery-Goulart, {Maria Teresa} and Fl{\'a}via Patroc{\'i}nio and Foss, {Maria Paula} and Vitor Tumas and Lima-Silva, {Tha{\'i}s Bento} and Brucki, {S{\^o}nia Maria Dozzi} and Ricardo Nitrini and {Della Sala}, Sergio and Parra, {Mario A.}",
year = "2017",
month = "10",
day = "31",
doi = "10.1007/s00415-017-8614-9",
language = "English",
volume = "264",
pages = "2162--2169",
journal = "Journal of Neurology",
issn = "0340-5354",
number = "10",

}

Cecchini, MA, Yassuda, MS, Bahia, VS, de Souza, LC, Guimarães, HC, Caramelli, P, Carthery-Goulart, MT, Patrocínio, F, Foss, MP, Tumas, V, Lima-Silva, TB, Brucki, SMD, Nitrini, R, Della Sala, S & Parra, MA 2017, 'Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia' Journal of Neurology, vol. 264, no. 10, pp. 2162-2169. https://doi.org/10.1007/s00415-017-8614-9

Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia. / Cecchini, Mario Amore; Yassuda, Mônica Sanches; Bahia, Valéria Santoro; de Souza, Leonardo Cruz; Guimarães, Henrique Cerqueira; Caramelli, Paulo; Carthery-Goulart, Maria Teresa; Patrocínio, Flávia; Foss, Maria Paula; Tumas, Vitor; Lima-Silva, Thaís Bento; Brucki, Sônia Maria Dozzi; Nitrini, Ricardo; Della Sala, Sergio; Parra, Mario A.

In: Journal of Neurology, Vol. 264, No. 10, 31.10.2017, p. 2162-2169.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia

AU - Cecchini, Mario Amore

AU - Yassuda, Mônica Sanches

AU - Bahia, Valéria Santoro

AU - de Souza, Leonardo Cruz

AU - Guimarães, Henrique Cerqueira

AU - Caramelli, Paulo

AU - Carthery-Goulart, Maria Teresa

AU - Patrocínio, Flávia

AU - Foss, Maria Paula

AU - Tumas, Vitor

AU - Lima-Silva, Thaís Bento

AU - Brucki, Sônia Maria Dozzi

AU - Nitrini, Ricardo

AU - Della Sala, Sergio

AU - Parra, Mario A.

PY - 2017/10/31

Y1 - 2017/10/31

N2 - It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.

AB - It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.

KW - frontotemporal dementia

KW - Alzheimer disease

KW - memory disorders

U2 - 10.1007/s00415-017-8614-9

DO - 10.1007/s00415-017-8614-9

M3 - Article

VL - 264

SP - 2162

EP - 2169

JO - Journal of Neurology

T2 - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 10

ER -

Cecchini MA, Yassuda MS, Bahia VS, de Souza LC, Guimarães HC, Caramelli P et al. Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia. Journal of Neurology. 2017 Oct 31;264(10):2162-2169. https://doi.org/10.1007/s00415-017-8614-9