Rearrangement strategy for the synthesis of 2-aminoanilines

Achim Porzelle, Michael D Woodrow, Nicholas C. O. Tomkinson

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of Imidazole provides a simple and effective method for the preparation of synthetically versatile 2-aminoanilines. Reactions proceed in DMF at 40 degrees C, providing the products in up to 86% isolated yield.
Original languageEnglish
Pages (from-to)1492-1495
Number of pages4
JournalOrganic Letters
Volume12
Issue number7
DOIs
Publication statusPublished - 2 Apr 2010

Keywords

  • privileged structures
  • hydroxylamines
  • chemistry
  • iodides

Fingerprint Dive into the research topics of 'Rearrangement strategy for the synthesis of 2-aminoanilines'. Together they form a unique fingerprint.

  • Cite this