Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics

C.A. Cunha Matos; O.M. Millington; A. W. Wark; M. Zagnoni

Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics

C.A. Cunha Matos, O.M. Millington, A. W. Wark, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

We present an interdisciplinary approach that allows for the evaluation of nanoparticle cytotoxicity at the single-cell level. By combining single-cell microfluidics with nanoparticle chemistry, real-time and high-throughput multimodal imaging of cellular interactions with functionalised gold nanorods was
successfully achieved. The integration of such techniques into tools for high-resolution cell monitoring and drug screening has, to the best of our knowledge, not been reported.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Place of Publication	San Diego, CA.
Pages	968-970
Number of pages	3
Publication status	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - Texas, San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

multimodal imaging
nanoparticles
cell interactions
single-cell
gold nanoparticles
nanotoxicity
high-throughput assay

Cite this

@inproceedings{7ef5c0dc0fab43f78d4faef4d8c8e7cb,

title = "Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics",

abstract = "We present an interdisciplinary approach that allows for the evaluation of nanoparticle cytotoxicity at the single-cell level. By combining single-cell microfluidics with nanoparticle chemistry, real-time and high-throughput multimodal imaging of cellular interactions with functionalised gold nanorods was successfully achieved. The integration of such techniques into tools for high-resolution cell monitoring and drug screening has, to the best of our knowledge, not been reported. ",

keywords = "multimodal imaging, nanoparticles, cell interactions, single-cell, gold nanoparticles, nanotoxicity, high-throughput assay",

author = "{Cunha Matos}, C.A. and O.M. Millington and Wark, {A. W.} and M. Zagnoni",

year = "2014",

language = "English",

isbn = "9781634396974",

pages = "968--970",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)",

note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) ; Conference date: 26-10-2014 Through 30-10-2014",

}

Cunha Matos, CA, Millington, OM, Wark, AW & Zagnoni, M 2014, Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014). San Diego, CA., pp. 968-970, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), San Antonio, United States, 26/10/14.

Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics. / Cunha Matos, C.A.; Millington, O.M.; Wark, A. W. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014). San Diego, CA., 2014. p. 968-970.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics

AU - Cunha Matos, C.A.

AU - Millington, O.M.

AU - Wark, A. W.

AU - Zagnoni, M.

PY - 2014

Y1 - 2014

N2 - We present an interdisciplinary approach that allows for the evaluation of nanoparticle cytotoxicity at the single-cell level. By combining single-cell microfluidics with nanoparticle chemistry, real-time and high-throughput multimodal imaging of cellular interactions with functionalised gold nanorods was successfully achieved. The integration of such techniques into tools for high-resolution cell monitoring and drug screening has, to the best of our knowledge, not been reported.

AB - We present an interdisciplinary approach that allows for the evaluation of nanoparticle cytotoxicity at the single-cell level. By combining single-cell microfluidics with nanoparticle chemistry, real-time and high-throughput multimodal imaging of cellular interactions with functionalised gold nanorods was successfully achieved. The integration of such techniques into tools for high-resolution cell monitoring and drug screening has, to the best of our knowledge, not been reported.

KW - multimodal imaging

KW - nanoparticles

KW - cell interactions

KW - single-cell

KW - gold nanoparticles

KW - nanotoxicity

KW - high-throughput assay

UR - http://microtasconferences.org/microtas2014/

UR - http://www.rsc.org/images/loc/2014/PDFs/Papers/318_0578.pdf

M3 - Conference contribution book

SN - 9781634396974

SP - 968

EP - 970

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)

CY - San Diego, CA.

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)

Y2 - 26 October 2014 through 30 October 2014

ER -

Real-time multimodal imaging of nanoparticle-cell interactions in high-throughput microfluidics

Abstract

Conference

Keywords

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