Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

Roger Domingo-Roca; Brian Saltin; James Windmill; Joseph Jackson; Helen Mulvana

doi:10.1109/ULTSYM.2019.8925741

Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

Roger Domingo-Roca, Brian Saltin, James Windmill, Joseph Jackson, Helen Mulvana

Electronic And Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

2 Citations (Scopus)

36 Downloads (Pure)

Abstract

The ability to undertake controlled and accurate investigation of the complex features that determine microvasculature-fluid systems is essential in our progress towards successful clinical exploitation of ultrasound mediated targeted drug delivery (UmTDD). We present an engineered platform to enable accurate understanding of the microvascular flow characteristics capable of influencing UmTDD. We develop novel 3D-printed flow phantoms, accurately replicating real microvascular structures, and a new approach to investigating UmTDD phenomena that places microbubble-microvessel interactions at the heart of the problem. Our aim is to establish a robust, lab-based platform for controlled and systematic investigation of microvessel architectures as key determinants in UmTDD efficiency.

Original language	English
Title of host publication	2019 IEEE International Ultrasonics Symposium, IUS 2019
Place of Publication	Piscataway, N.J.
Pages	2390-2393
Number of pages	4
ISBN (Electronic)	9781728145969
DOIs	https://doi.org/10.1109/ULTSYM.2019.8925741
Publication status	Published - 6 Dec 2019
Event	2019 IEEE International Ultrasonics Symposium: IEEE UFFC - SECC, Glasgow, United Kingdom Duration: 6 Oct 2019 → 9 Oct 2019 https://attend.ieee.org/ius-2019/

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
Volume	2019-October
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2019 IEEE International Ultrasonics Symposium
Abbreviated title	IUS 2019
Country/Territory	United Kingdom
City	Glasgow
Period	6/10/19 → 9/10/19
Internet address	https://attend.ieee.org/ius-2019/

Keywords

3D-Printing
microCT
microvasculature
phantom
ultrasound-mediated targeted drug delivery

Access to Document

10.1109/ULTSYM.2019.8925741

Domingo-Roca-etal-IEEE-IUS-2019-Rapid-prototyped-microvessel-flow-phantom-for-controlledAccepted author manuscript, 403 KB

Cite this

Domingo-Roca, R., Saltin, B., Windmill, J., Jackson, J., & Mulvana, H. (2019). Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 2390-2393). (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October).. https://doi.org/10.1109/ULTSYM.2019.8925741

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title = "Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery",

abstract = "The ability to undertake controlled and accurate investigation of the complex features that determine microvasculature-fluid systems is essential in our progress towards successful clinical exploitation of ultrasound mediated targeted drug delivery (UmTDD). We present an engineered platform to enable accurate understanding of the microvascular flow characteristics capable of influencing UmTDD. We develop novel 3D-printed flow phantoms, accurately replicating real microvascular structures, and a new approach to investigating UmTDD phenomena that places microbubble-microvessel interactions at the heart of the problem. Our aim is to establish a robust, lab-based platform for controlled and systematic investigation of microvessel architectures as key determinants in UmTDD efficiency.",

keywords = "3D-Printing, microCT, microvasculature, phantom, ultrasound-mediated targeted drug delivery",

author = "Roger Domingo-Roca and Brian Saltin and James Windmill and Joseph Jackson and Helen Mulvana",

note = "{\textcopyright} 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.; 2019 IEEE International Ultrasonics Symposium : IEEE UFFC, IUS 2019 ; Conference date: 06-10-2019 Through 09-10-2019",

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doi = "10.1109/ULTSYM.2019.8925741",

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Domingo-Roca, R, Saltin, B, Windmill, J, Jackson, J & Mulvana, H 2019, Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery. in 2019 IEEE International Ultrasonics Symposium, IUS 2019. IEEE International Ultrasonics Symposium, IUS, vol. 2019-October, Piscataway, N.J., pp. 2390-2393, 2019 IEEE International Ultrasonics Symposium, Glasgow, United Kingdom, 6/10/19. https://doi.org/10.1109/ULTSYM.2019.8925741

Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery. / Domingo-Roca, Roger; Saltin, Brian; Windmill, James et al.
2019 IEEE International Ultrasonics Symposium, IUS 2019. Piscataway, N.J., 2019. p. 2390-2393 (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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N1 - © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

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Rapid prototyped microvessel flow phantom for controlled investigation of ultrasound-mediated targeted drug delivery

Abstract

Publication series

Conference

Keywords

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3D-printed high-resolution phantom microvasculature enables measurement of microbubble acoustic backscattering

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