Rapid fabrication of polymer microfluidic systems for the production of artificial lipid bilayers

M E Sandison, H Morgan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A polymer microfluidic device has been fabricated using rapid prototyping techniques. The device was built to allow the formation and subsequent investigation of artificial bilayer lipid membranes (BLMs). A simple dry film photoresist stamp was used to hot emboss microfluidic channels into PMMA films. Laser micromachining was employed to form an aperture through the PMMA channels, across which the BLM was later formed. The dry film photoresist was also used as a simple etch mask for the deep etching of glass substrates in buffered HF solutions, which was used in this work for the production of glass embossing stamps. We show that bilayer films can be successfully produced across laser micromachined apertures in PMMA films.

Original languageEnglish
Pages (from-to)S139-S144
Number of pages6
JournalJournal of Micromechanics and Microengineering
Volume15
Issue number7
Early online date20 Jun 2005
DOIs
Publication statusPublished - 1 Jul 2005

Fingerprint

Lipid bilayers
Microfluidics
lipids
Polymers
Fabrication
Polymethyl Methacrylate
fabrication
polymers
Photoresists
Membrane Lipids
photoresists
apertures
membranes
Glass
rapid prototyping
embossing
laser machining
Lasers
glass
microfluidic devices

Keywords

  • polymer microfluidic devices
  • bilayer lipid membranes
  • laser micromachining
  • microfabrication

Cite this

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Rapid fabrication of polymer microfluidic systems for the production of artificial lipid bilayers. / Sandison, M E; Morgan, H.

In: Journal of Micromechanics and Microengineering, Vol. 15, No. 7, 01.07.2005, p. S139-S144.

Research output: Contribution to journalArticle

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