This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.
- antisolvent crystallization
- crystal structures
Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., ... Oswald, I. D. H. (2018). Rapid continuous antisolvent crystallization of multi-component systems. Crystal Growth and Design, 18(1), 210-218. https://doi.org/10.1021/acs.cgd.7b01105