Rapid continuous antisolvent crystallization of multi-component systems

Syed A. Raza, Ulrich Schacht, Vaclav Svoboda, Darren P. Edwards, Alastair J. Florence, Colin R. Pulham, Jan Sefcik, Iain D. H. Oswald

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Abstract

This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.
Original languageEnglish
Pages (from-to)210-218
Number of pages9
JournalCrystal Growth and Design
Volume18
Issue number1
Early online date27 Nov 2017
DOIs
Publication statusPublished - 3 Jan 2018

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Keywords

  • antisolvent crystallization
  • crystal structures
  • crystallization

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