Raman optical activity (ROA) is a relatively new technique used to determine the structure of chiral molecules and is proving useful in the study of biological molecules such as proteins and DNA/RNA. Here, for the first time, we demonstrate the applicability of ROA as a technique to study achiral groups in chiral environments, detecting the induced chirality of N-(fluorenyl-9-methoxycarbonyl) (Fmoc) in a chiral self-assembled structure of Fmoc-dipeptides. This technique is therefore of interest to those studying self-assembled systems that adopt a chiral structure.
- raman optical activity
Smith, A. M., Collins, R. F., Ulijn, R. V., & Blanch, E. (2009). Raman optical activity of an achiral element in a chiral environment. Journal of Raman Spectroscopy, 40(9), 1093-1095. https://doi.org/10.1002/jrs.2390