Projects per year
Abstract
A pallette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quantitatively ranked based on the results of intermolecular hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructred from these data reveal a wide range of reactivity covering four orders of magnitude. Intramolecular competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within molecules with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalysed C-H activation reactions.
Original language | English |
---|---|
Type | Preprint |
Media of output | |
Number of pages | 6 |
Place of Publication | [London] |
DOIs | |
Publication status | Published - 2 Jul 2020 |
Keywords
- isotopic labelling
- iridium catalysis
- reaction selectivity
- C-H activation
Fingerprint
Dive into the research topics of 'Quantitative prediction of selectivity in iridium-catalysed hydrogen isotope exchange reactions'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Defining, Quantifying, and Understanding Selectivity Paradigms in Iridium-Cataly
1/10/18 → 31/12/22
Project: Research
Datasets
-
Data for: "A quantitative empirical directing group scale for selectivity in iridium-catalysed hydrogen isotope exchange reactions"
Timofeeva, D. (Creator), Lindsay, D. (Creator), Kerr, W. (Creator) & Nelson, D. (Creator), University of Strathclyde, 7 Sep 2020
DOI: 10.15129/46bc02ea-f605-44f5-978c-fd7852fbdc19
Dataset