Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography

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Abstract

The implementation of a particle design platform that can be applied to novel pharmaceutical systems using acoustic levitation (SAL) and X-ray tomography (XRT) is discussed. Acoustic levitation was employed to provide a container-less particle design environment for single droplet evaporation experiments. Dried particles were subject to further visual and quantitative structural analysis using X-ray tomography to assess the three-dimensional volume space. The workflow of the combined SAL-XRT platform has been applied to investigate the impact of increasing HPMC K100LV concentrations on the evaporation, drying and final particle morphology of particles from a model pharmaceutical formulation containing metformin and D-mannitol. The morphology and internal structure of the formulated particles after drying are dominated by a crystalline core of D-mannitol partially suppressed with increasing HPMC K100LV additions. The final structure can be correlated to the observed evaporation kinetics. The characterisation and its influence on the final particle morphology can enable the selection of process conditions that deliver the desired particle structure and consequent performance by design.
Original languageEnglish
Pages (from-to)2996-3006
Number of pages11
JournalAdvanced Powder Technology
Volume29
Issue number12
Early online date12 Oct 2018
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • pharmaceutical formulation development
  • acoustic levitation
  • crystallisation
  • XRT particle structure analysis
  • single droplet evaporation

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