Projects per year
Abstract
The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce bulk quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.
Original language | English |
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Pages (from-to) | 359-366 |
Number of pages | 8 |
Journal | CrystEngComm |
Volume | 11 |
Issue number | 2 |
Early online date | 28 Nov 2008 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- crystallisation
- polymorphs
- solvates
- molecular compounds
- high pressure
- metastable form
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Dive into the research topics of 'Putting pressure on elusive polymorphs and solvates'. Together they form a unique fingerprint.Projects
- 1 Finished
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Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research