Putrescine bisamides from Aglaia gigantea

Tu Ngoc Duong, RuAngelie Edrada, Rainer Ebel, Victor Wray, Walter Frank, Anh Tuan Duong, Wen Han Lin, Peter Proksch, Ruangelie Edrada-Ebel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide ( 1), as well as two new natural products, gigantamide A ( 2) and grandiamide D ( 3). In this study, the structure of dasyclamide ( 1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A ( 2) and grandiamide D ( 3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D ( 3) was determined via Mosher ester derivatization.

Original languageEnglish
Pages (from-to)1640-1643
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • aglaia
  • crystallography, X-Ray
  • molecular conformation
  • molecular structure
  • nuclear magnetic resonance, Biomolecular
  • plant leaves
  • plants, Medicinal
  • putrescine
  • Vietnam

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  • Cite this

    Duong, T. N., Edrada, R., Ebel, R., Wray, V., Frank, W., Duong, A. T., Lin, W. H., Proksch, P., & Edrada-Ebel, R. (2007). Putrescine bisamides from Aglaia gigantea. Journal of Natural Products, 70(10), 1640-1643. https://doi.org/10.1021/np070184w