Pushing the limits

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In 1997, Kneipp et al. and Nie and Emory independently reported the first examples of single-molecule detection using surface-enhanced Raman scattering (SERS). These seminal works sparked a surge of interest in SERS, while introducing a new question: how can it be conclusively proven that just one molecule is being probed?
Original languageEnglish
Pages (from-to)842-843
Number of pages2
JournalNature Reviews Chemistry
Issue number12
Early online date17 Nov 2022
Publication statusPublished - 31 Dec 2022


  • vibrational spectroscopies
  • silver nanoparticles
  • Raman spectroscopy


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