Pulsed UV-light inactivation of poliovirus and adenovirus

Y. Lamont; A. Rzeutka; J.G. Anderson; S.J. MacGregor; M.J. Given; C. Deppe; N. Cook

doi:10.1111/j.1472-765X.2007.02261.x

Pulsed UV-light inactivation of poliovirus and adenovirus

Y. Lamont, A. Rzeutka, J.G. Anderson, S.J. MacGregor, M.J. Given, C. Deppe, N. Cook

Electronic And Electrical Engineering

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Aims: To study the pulsed ultraviolet (UV) inactivation of poliovirus and adenovirus.

Methods and Results: Viral suspensions of 2ml volume were exposed to varying numbers of polychromatic light pulses emitted from a xenon flashlamp. Ten pulses produced an approximately 4 log10 reduction in poliovirus titre, and no infectious poliovirus remained after 25 pulses. With adenovirus, 10 pulses resulted in an approximately 1 log10 reduction in infectivity. Adenovirus required 100 pulses to produce an approximately 3 log10 reduction in infectivity, and 200 pulses to produce a greater than 4 log10 reduction.

Conclusions: Adenovirus was more resistant to pulsed UV treatment than poliovirus although both viruses showed susceptibility to the treatment.

Significance and Impact of the Study: Pulsed UV-light treatment proved successful in the inactivation of poliovirus and adenovirus, and represents an alternative to continuous-wave UV treatment.

Original language	English
Pages (from-to)	564-567
Number of pages	4
Journal	Letters in Applied Microbiology
Volume	45
Issue number	5
Early online date	17 Oct 2007
DOIs	https://doi.org/10.1111/j.1472-765X.2007.02261.x
Publication status	Published - 30 Nov 2007

Keywords

adenovirus
poliovirus
pulsed
ultraviolet light
UV inactivation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1472-765X.2007.02261.x

Cite this

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title = "Pulsed UV-light inactivation of poliovirus and adenovirus",

abstract = "Aims: To study the pulsed ultraviolet (UV) inactivation of poliovirus and adenovirus. Methods and Results: Viral suspensions of 2ml volume were exposed to varying numbers of polychromatic light pulses emitted from a xenon flashlamp. Ten pulses produced an approximately 4 log10 reduction in poliovirus titre, and no infectious poliovirus remained after 25 pulses. With adenovirus, 10 pulses resulted in an approximately 1 log10 reduction in infectivity. Adenovirus required 100 pulses to produce an approximately 3 log10 reduction in infectivity, and 200 pulses to produce a greater than 4 log10 reduction. Conclusions: Adenovirus was more resistant to pulsed UV treatment than poliovirus although both viruses showed susceptibility to the treatment. Significance and Impact of the Study: Pulsed UV-light treatment proved successful in the inactivation of poliovirus and adenovirus, and represents an alternative to continuous-wave UV treatment.",

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T1 - Pulsed UV-light inactivation of poliovirus and adenovirus

AU - Lamont, Y.

AU - Rzeutka, A.

AU - Anderson, J.G.

AU - MacGregor, S.J.

AU - Given, M.J.

AU - Deppe, C.

AU - Cook, N.

PY - 2007/11/30

Y1 - 2007/11/30

N2 - Aims: To study the pulsed ultraviolet (UV) inactivation of poliovirus and adenovirus. Methods and Results: Viral suspensions of 2ml volume were exposed to varying numbers of polychromatic light pulses emitted from a xenon flashlamp. Ten pulses produced an approximately 4 log10 reduction in poliovirus titre, and no infectious poliovirus remained after 25 pulses. With adenovirus, 10 pulses resulted in an approximately 1 log10 reduction in infectivity. Adenovirus required 100 pulses to produce an approximately 3 log10 reduction in infectivity, and 200 pulses to produce a greater than 4 log10 reduction. Conclusions: Adenovirus was more resistant to pulsed UV treatment than poliovirus although both viruses showed susceptibility to the treatment. Significance and Impact of the Study: Pulsed UV-light treatment proved successful in the inactivation of poliovirus and adenovirus, and represents an alternative to continuous-wave UV treatment.

AB - Aims: To study the pulsed ultraviolet (UV) inactivation of poliovirus and adenovirus. Methods and Results: Viral suspensions of 2ml volume were exposed to varying numbers of polychromatic light pulses emitted from a xenon flashlamp. Ten pulses produced an approximately 4 log10 reduction in poliovirus titre, and no infectious poliovirus remained after 25 pulses. With adenovirus, 10 pulses resulted in an approximately 1 log10 reduction in infectivity. Adenovirus required 100 pulses to produce an approximately 3 log10 reduction in infectivity, and 200 pulses to produce a greater than 4 log10 reduction. Conclusions: Adenovirus was more resistant to pulsed UV treatment than poliovirus although both viruses showed susceptibility to the treatment. Significance and Impact of the Study: Pulsed UV-light treatment proved successful in the inactivation of poliovirus and adenovirus, and represents an alternative to continuous-wave UV treatment.

KW - adenovirus

KW - poliovirus

KW - pulsed

KW - ultraviolet light

KW - UV inactivation

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DO - 10.1111/j.1472-765X.2007.02261.x

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EP - 567

JO - Letters in Applied Microbiology

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Pulsed UV-light inactivation of poliovirus and adenovirus

Abstract

Keywords

UN SDGs

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