Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Over recent decades biotechnology has made significant advances owing to the emergence of powerful biochemical and biophysical instrumentation. The development of such technologies has enabled high-throughput assessment of compounds, the implementation of recombinant DNA technology, and large-scale manufacture of monoclonal antibodies. Such innovations have ultimately resulted in the current experienced biopharmaceutical stronghold in the therapeutic market. Yet aggregate prediction and profiling remains a challenge in the formulation of biopharmaceuticals due to artifacts associated with each analytical method. We review some emerging trends and novel technologies that offer a promising potential for accurately predicting and profiling protein aggregation at various stages of biopharmaceutical product design.
Original languageEnglish
Pages (from-to)448-458
Number of pages11
JournalTrends in Biotechnology
Volume31
Issue number8
DOIs
Publication statusPublished - 14 Jun 2013

Keywords

  • aggregation
  • biopharmaceuticals
  • manufacture
  • product development
  • quality by design
  • biopharmaceutical aggregation

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