Proteinase-activated receptors (PARs)

Margaret Rose Cunningham; Robin Plevin

doi:10.1007/978-3-540-38918-7_122

Proteinase-activated receptors (PARs)

Margaret Rose Cunningham, Robin Plevin

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.

Original language	English
Title of host publication	Encyclopedia of Molecular Pharmacology
Editors	Stefan Offermanns, Walter Rosenthal
Place of Publication	Berlin
Publisher	Springer
Pages	1019-1023
Number of pages	4
ISBN (Electronic)	9783540389163
DOIs	https://doi.org/10.1007/978-3-540-38918-7_122
Publication status	Published - Aug 2008

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10.1007/978-3-540-38918-7_122

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title = "Proteinase-activated receptors (PARs)",

abstract = "Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.",

author = "Cunningham, {Margaret Rose} and Robin Plevin",

year = "2008",

month = aug,

doi = "10.1007/978-3-540-38918-7_122",

language = "English",

pages = "1019--1023",

editor = "Stefan Offermanns and Walter Rosenthal",

booktitle = "Encyclopedia of Molecular Pharmacology",

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AU - Plevin, Robin

PY - 2008/8

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N2 - Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.

AB - Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.

UR - http://link.springer.com/book/10.1007/978-3-540-38918-7

U2 - 10.1007/978-3-540-38918-7_122

DO - 10.1007/978-3-540-38918-7_122

M3 - Entry for encyclopedia/dictionary

SP - 1019

EP - 1023

BT - Encyclopedia of Molecular Pharmacology

A2 - Offermanns, Stefan

A2 - Rosenthal, Walter

PB - Springer

CY - Berlin

ER -

Proteinase-activated receptors (PARs)

Abstract

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