Proteinase-activated receptors (PARs)

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.
LanguageEnglish
Title of host publicationEncyclopedia of Molecular Pharmacology
EditorsStefan Offermanns, Walter Rosenthal
Place of PublicationBerlin
PublisherSpringer
Pages1019-1023
Number of pages4
ISBN (Electronic)9783540389163
DOIs
Publication statusPublished - Aug 2008

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Proteinase-Activated Receptors
PAR-1 Receptor
Thrombin
Trypsin
PAR-2 Receptor
Serine Proteases
G-Protein-Coupled Receptors
Peptide Hydrolases

Cite this

Cunningham, M. R., & Plevin, R. (2008). Proteinase-activated receptors (PARs). In S. Offermanns, & W. Rosenthal (Eds.), Encyclopedia of Molecular Pharmacology (pp. 1019-1023). Berlin: Springer. https://doi.org/10.1007/978-3-540-38918-7_122
Cunningham, Margaret Rose ; Plevin, Robin. / Proteinase-activated receptors (PARs). Encyclopedia of Molecular Pharmacology. editor / Stefan Offermanns ; Walter Rosenthal. Berlin : Springer, 2008. pp. 1019-1023
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Cunningham, MR & Plevin, R 2008, Proteinase-activated receptors (PARs). in S Offermanns & W Rosenthal (eds), Encyclopedia of Molecular Pharmacology. Springer, Berlin, pp. 1019-1023. https://doi.org/10.1007/978-3-540-38918-7_122

Proteinase-activated receptors (PARs). / Cunningham, Margaret Rose; Plevin, Robin.

Encyclopedia of Molecular Pharmacology. ed. / Stefan Offermanns; Walter Rosenthal. Berlin : Springer, 2008. p. 1019-1023.

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

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AB - Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.

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BT - Encyclopedia of Molecular Pharmacology

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Cunningham MR, Plevin R. Proteinase-activated receptors (PARs). In Offermanns S, Rosenthal W, editors, Encyclopedia of Molecular Pharmacology. Berlin: Springer. 2008. p. 1019-1023 https://doi.org/10.1007/978-3-540-38918-7_122