Proteinase-activated receptors (PARs)

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Abstract

Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.
Original languageEnglish
Title of host publicationEncyclopedia of Molecular Pharmacology
EditorsStefan Offermanns, Walter Rosenthal
Place of PublicationBerlin
PublisherSpringer
Pages1019-1023
Number of pages4
ISBN (Electronic)9783540389163
DOIs
Publication statusPublished - Aug 2008

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