Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Roua Abulkassim; Ros Brett; Scott M. MacKenzie; Trevor J. Bushell

doi:10.1016/j.jneuroim.2016.04.016

Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Roua Abulkassim, Ros Brett, Scott M. MacKenzie, Trevor J. Bushell

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.

Original language	English
Pages (from-to)	139-147
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	295-296
Early online date	27 Apr 2016
DOIs	https://doi.org/10.1016/j.jneuroim.2016.04.016
Publication status	Published - 13 May 2016

Keywords

proteinase-activated receptor-2
LPS
sickness behaviour
locomotor activity
anxiety
sucrose preference

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10.1016/j.jneuroim.2016.04.016

Abulkassim-etal-JNI-2016-Proteinase-activated-receptor-2-is-involved-in-the-behaviouralAccepted author manuscript, 408 KBLicence: CC BY-NC-ND 4.0

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title = "Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour",

abstract = "Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes. ",

keywords = "proteinase-activated receptor-2, LPS, sickness behaviour, locomotor activity, anxiety, sucrose preference",

author = "Roua Abulkassim and Ros Brett and MacKenzie, {Scott M.} and Bushell, {Trevor J.}",

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doi = "10.1016/j.jneuroim.2016.04.016",

language = "English",

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pages = "139--147",

journal = "Journal of Neuroimmunology",

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T1 - Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

AU - Abulkassim, Roua

AU - Brett, Ros

AU - MacKenzie, Scott M.

AU - Bushell, Trevor J.

PY - 2016/5/13

Y1 - 2016/5/13

N2 - Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.

AB - Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.

KW - proteinase-activated receptor-2

KW - LPS

KW - sickness behaviour

KW - locomotor activity

KW - anxiety

KW - sucrose preference

UR - http://www.sciencedirect.com/science/article/pii/S0165572816300935

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DO - 10.1016/j.jneuroim.2016.04.016

M3 - Article

SN - 0165-5728

VL - 295-296

SP - 139

EP - 147

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

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