Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Roua Abulkassim, Ros Brett, Scott M. MacKenzie, Trevor J. Bushell

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Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.
Original languageEnglish
Pages (from-to)139-147
Number of pages8
JournalJournal of Neuroimmunology
Early online date27 Apr 2016
Publication statusPublished - 13 May 2016


  • proteinase-activated receptor-2
  • LPS
  • sickness behaviour
  • locomotor activity
  • anxiety
  • sucrose preference

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