Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Roua Abulkassim, Ros Brett, Scott M. MacKenzie, Trevor J. Bushell

Research output: Contribution to journalArticle

Abstract

Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.
LanguageEnglish
Pages139-147
Number of pages8
JournalJournal of Neuroimmunology
Volume295-296
Early online date27 Apr 2016
DOIs
Publication statusPublished - 13 May 2016

Fingerprint

PAR-2 Receptor
Illness Behavior
Inflammation
Transgenic Mice
Brain

Keywords

  • proteinase-activated receptor-2
  • LPS
  • sickness behaviour
  • locomotor activity
  • anxiety
  • sucrose preference

Cite this

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abstract = "Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2-/- mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.",
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Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour. / Abulkassim, Roua; Brett, Ros; MacKenzie, Scott M.; Bushell, Trevor J.

In: Journal of Neuroimmunology, Vol. 295-296, 13.05.2016, p. 139-147.

Research output: Contribution to journalArticle

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