Proteinase activated receptor 2: a novel therapeutic drug target

Original language	English
Publication status	Published - 8 Feb 2024
Event	2nd AUU Health and biomedical postgraduate Symposium - Dubai Duration: 8 Feb 2024 → 8 Feb 2024

Conference

Conference	2nd AUU Health and biomedical postgraduate Symposium
Period	8/02/24 → 8/02/24

Keywords

• PAR2
• pharmacology
• proteinase activated receptor 2

Projects

Projects per year 2020 2020 2023 2027

• 1 Finished
• 1 Active

Projects per year

• Development of novel PAR2 antagonists to treat inflammatory disease

  McIntosh, K.

  5/02/23 → 29/08/27

  Project: Research

  • Inflammatory Disease 100%
  • G Protein Coupled Receptor 50%
  • Arthritis 50%
  • Receptor 50%

• Development and preclinical validation of novel PAR2 inhibitors for the treatment of Osteoarthritis

  McIntosh, K., Crilly, A., Jamieson, C., Plevin, R. & Rattray, Z.

  Tenovus Scotland

  1/04/20 → 30/09/22

  Project: Research

  • Internalization 100%
  • Calcium Mobilization 66%
  • Cell Clone 33%
  • Signaling Mechanism 33%
  • Receptor down Regulation 33%

Research output

Research output per year 2015 2015 2020 2020

• 1 Abstract
• 1 Review article

Research output per year

Research output per year

• The development of proteinase-activated receptor-2 modulators and the challenges involved

  McIntosh, K. A., Cunningham, M. R., Bushell, T. & Plevin, R., 31 Dec 2020, In: Biochemical Society Transactions. 48, 6, p. 2525-2537 13 p., BST20200191.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Proteinase Activated Receptor 2 100%
  • Peptide 23%
  • Antagonist 23%
  • Antibody 23%
  • Ligand 15%
  22 Citations (Scopus)

  237 Downloads (Pure)

• Working towards proteinase activated receptor-2 antagonists

  McIntosh, K. A., Jamieson, C. & Plevin, R. J., 13 Dec 2015. 1 p.

  Research output: Contribution to conference › Abstract › peer-review

  • Internalization 100%
  • Calcium Mobilization 66%
  • Cell Clone 33%
  • Signaling Mechanism 33%
  • Receptor down Regulation 33%

Student theses

• Characterisation of novel compounds as antagonists of protease-activated receptor-2 (PAR2)

  Author: Saeed, T. S. S., 28 Jan 2019

  Supervisor: Plevin, R. (Supervisor) & Paul, A. (Supervisor)

  Student thesis: Doctoral Thesis

Activities

Activities per year 2020 2020 2020

• 1 Invited talk

Activities per year

• A history of PAR2 drug design

  Kathryn McIntosh (Speaker)

  9 Dec 2020

  Activity: Talk or presentation types › Invited talk

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Lozon, Y., McIntosh, K., & Plevin, R. (2024). Proteinase activated receptor 2: a novel therapeutic drug target. Poster session presented at 2nd AUU Health and biomedical postgraduate Symposium.

Lozon, Yosra ; McIntosh, Kathryn ; Plevin, Robin. / Proteinase activated receptor 2 : a novel therapeutic drug target. Poster session presented at 2nd AUU Health and biomedical postgraduate Symposium.

@conference{150ee5d57f934ec18832fd8297fc7bc0,

title = "Proteinase activated receptor 2: a novel therapeutic drug target",

keywords = "PAR2, pharmacology, proteinase activated receptor 2",

author = "Yosra Lozon and Kathryn McIntosh and Robin Plevin",

year = "2024",

month = feb,

day = "8",

language = "English",

note = "2nd AUU Health and biomedical postgraduate Symposium ; Conference date: 08-02-2024 Through 08-02-2024",

}

Lozon, Y, McIntosh, K & Plevin, R 2024, 'Proteinase activated receptor 2: a novel therapeutic drug target', 2nd AUU Health and biomedical postgraduate Symposium, 8/02/24 - 8/02/24.

Proteinase activated receptor 2: a novel therapeutic drug target. / Lozon, Yosra; McIntosh, Kathryn; Plevin, Robin.
2024. Poster session presented at 2nd AUU Health and biomedical postgraduate Symposium.

Research output: Contribution to conference › Poster

TY - CONF

T1 - Proteinase activated receptor 2

T2 - 2nd AUU Health and biomedical postgraduate Symposium

AU - Lozon, Yosra

AU - McIntosh, Kathryn

AU - Plevin, Robin

PY - 2024/2/8

Y1 - 2024/2/8

KW - PAR2

KW - pharmacology

KW - proteinase activated receptor 2

M3 - Poster

Y2 - 8 February 2024 through 8 February 2024

ER -

Lozon Y, McIntosh K, Plevin R. Proteinase activated receptor 2: a novel therapeutic drug target. 2024. Poster session presented at 2nd AUU Health and biomedical postgraduate Symposium.