Abstract
Biomineralisation, due to its remarkable sophistication and hierarchical control in mineral 'shaping', is profoundly inspiring for the design of novel materials and new processes. Recent investigations have begun to elucidate the specific interactions of various biomolecules with their respective minerals in vivo. In order to better understand the roles of such (bio)molecules in (bio)mineralisation, various in vitro model systems have been examined recently. Here we report the bioinspired mineralisation of silica in the presence of a lysine and arginine rich a-helical synthetic protein YT320 that was tailor-made using genetic engineering. Furthermore, in order to examine the possible specificity (or perhaps the lack thereof) of this protein with silica, we also report studies of bioinspired mineralisation of germania. It is proposed that this protein facilitates and 'guides' the mineralisation through residue specific and conformationally directed interactions at the molecular level.
| Language | English |
|---|---|
| Pages | 150-163 |
| Number of pages | 14 |
| Journal | ACS Symposium Series |
| Volume | 900 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- silicic-acid polymerization
- neutral ph
- sodium-silicate
- colloidal silica
- diatoms
- peptides
- silicification
Cite this
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Protein-mediated bioinspired mineralization. / Patwardhan, S V ; Shiba, K ; Raab, C ; Huesing, N ; Clarson, S J .
In: ACS Symposium Series, Vol. 900, 2005, p. 150-163.Research output: Contribution to journal › Article
TY - JOUR
T1 - Protein-mediated bioinspired mineralization
AU - Patwardhan, S V
AU - Shiba, K
AU - Raab, C
AU - Huesing, N
AU - Clarson, S J
PY - 2005
Y1 - 2005
N2 - Biomineralisation, due to its remarkable sophistication and hierarchical control in mineral 'shaping', is profoundly inspiring for the design of novel materials and new processes. Recent investigations have begun to elucidate the specific interactions of various biomolecules with their respective minerals in vivo. In order to better understand the roles of such (bio)molecules in (bio)mineralisation, various in vitro model systems have been examined recently. Here we report the bioinspired mineralisation of silica in the presence of a lysine and arginine rich a-helical synthetic protein YT320 that was tailor-made using genetic engineering. Furthermore, in order to examine the possible specificity (or perhaps the lack thereof) of this protein with silica, we also report studies of bioinspired mineralisation of germania. It is proposed that this protein facilitates and 'guides' the mineralisation through residue specific and conformationally directed interactions at the molecular level.
AB - Biomineralisation, due to its remarkable sophistication and hierarchical control in mineral 'shaping', is profoundly inspiring for the design of novel materials and new processes. Recent investigations have begun to elucidate the specific interactions of various biomolecules with their respective minerals in vivo. In order to better understand the roles of such (bio)molecules in (bio)mineralisation, various in vitro model systems have been examined recently. Here we report the bioinspired mineralisation of silica in the presence of a lysine and arginine rich a-helical synthetic protein YT320 that was tailor-made using genetic engineering. Furthermore, in order to examine the possible specificity (or perhaps the lack thereof) of this protein with silica, we also report studies of bioinspired mineralisation of germania. It is proposed that this protein facilitates and 'guides' the mineralisation through residue specific and conformationally directed interactions at the molecular level.
KW - silicic-acid polymerization
KW - neutral ph
KW - sodium-silicate
KW - colloidal silica
KW - diatoms
KW - peptides
KW - silicification
U2 - 10.1021/bk-2005-0900.ch011
DO - 10.1021/bk-2005-0900.ch011
M3 - Article
VL - 900
SP - 150
EP - 163
JO - ACS Symposium Series
T2 - ACS Symposium Series
JF - ACS Symposium Series
SN - 0097-6156
ER -