Protein-mediated bioinspired mineralization

S V Patwardhan, K Shiba, C Raab, N Huesing, S J Clarson

Research output: Contribution to journalArticle

Abstract

Biomineralisation, due to its remarkable sophistication and hierarchical control in mineral 'shaping', is profoundly inspiring for the design of novel materials and new processes. Recent investigations have begun to elucidate the specific interactions of various biomolecules with their respective minerals in vivo. In order to better understand the roles of such (bio)molecules in (bio)mineralisation, various in vitro model systems have been examined recently. Here we report the bioinspired mineralisation of silica in the presence of a lysine and arginine rich a-helical synthetic protein YT320 that was tailor-made using genetic engineering. Furthermore, in order to examine the possible specificity (or perhaps the lack thereof) of this protein with silica, we also report studies of bioinspired mineralisation of germania. It is proposed that this protein facilitates and 'guides' the mineralisation through residue specific and conformationally directed interactions at the molecular level.

LanguageEnglish
Pages150-163
Number of pages14
JournalACS Symposium Series
Volume900
DOIs
Publication statusPublished - 2005

Fingerprint

Biomineralization
Proteins
Silicon Dioxide
Minerals
Silica
Germanium
Genetic engineering
Arginine
Biomolecules
Lysine
Molecules

Keywords

  • silicic-acid polymerization
  • neutral ph
  • sodium-silicate
  • colloidal silica
  • diatoms
  • peptides
  • silicification

Cite this

Patwardhan, S. V., Shiba, K., Raab, C., Huesing, N., & Clarson, S. J. (2005). Protein-mediated bioinspired mineralization. ACS Symposium Series, 900, 150-163. https://doi.org/10.1021/bk-2005-0900.ch011
Patwardhan, S V ; Shiba, K ; Raab, C ; Huesing, N ; Clarson, S J . / Protein-mediated bioinspired mineralization. In: ACS Symposium Series. 2005 ; Vol. 900. pp. 150-163.
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Patwardhan, SV, Shiba, K, Raab, C, Huesing, N & Clarson, SJ 2005, 'Protein-mediated bioinspired mineralization' ACS Symposium Series, vol. 900, pp. 150-163. https://doi.org/10.1021/bk-2005-0900.ch011

Protein-mediated bioinspired mineralization. / Patwardhan, S V ; Shiba, K ; Raab, C ; Huesing, N ; Clarson, S J .

In: ACS Symposium Series, Vol. 900, 2005, p. 150-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protein-mediated bioinspired mineralization

AU - Patwardhan, S V

AU - Shiba, K

AU - Raab, C

AU - Huesing, N

AU - Clarson, S J

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AB - Biomineralisation, due to its remarkable sophistication and hierarchical control in mineral 'shaping', is profoundly inspiring for the design of novel materials and new processes. Recent investigations have begun to elucidate the specific interactions of various biomolecules with their respective minerals in vivo. In order to better understand the roles of such (bio)molecules in (bio)mineralisation, various in vitro model systems have been examined recently. Here we report the bioinspired mineralisation of silica in the presence of a lysine and arginine rich a-helical synthetic protein YT320 that was tailor-made using genetic engineering. Furthermore, in order to examine the possible specificity (or perhaps the lack thereof) of this protein with silica, we also report studies of bioinspired mineralisation of germania. It is proposed that this protein facilitates and 'guides' the mineralisation through residue specific and conformationally directed interactions at the molecular level.

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KW - neutral ph

KW - sodium-silicate

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KW - diatoms

KW - peptides

KW - silicification

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Patwardhan SV, Shiba K, Raab C, Huesing N, Clarson SJ. Protein-mediated bioinspired mineralization. ACS Symposium Series. 2005;900:150-163. https://doi.org/10.1021/bk-2005-0900.ch011