Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.
- arthritis research
- therapeutic treatment
Ferrell, W. R., Kelso, E. B., Lockhart, J. C., Burns, E., Plevin, R., & McInnes, I. B. (2011). Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis. Rheumatology, 50(Supplement 3), 90-90. https://doi.org/10.1093/rheumatology/ker157