Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

William R. Ferrell, Elizabeth B. Kelso, John C. Lockhart, Elizabeth Burns, Robin Plevin, Iain B. McInnes

Research output: Contribution to journalConference Contributionpeer-review

Abstract

Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.
Original languageEnglish
Pages (from-to)90-90
Number of pages1
JournalRheumatology
Volume50
Issue numberSupplement 3
DOIs
Publication statusPublished - Apr 2011

Keywords

  • osteoarthritis
  • protase
  • arthritis research
  • therapeutic treatment

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