Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.
- arthritis research
- therapeutic treatment