Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

William R. Ferrell; Elizabeth B. Kelso; John C. Lockhart; Elizabeth Burns; Robin Plevin; Iain B. McInnes

doi:10.1093/rheumatology/ker157

Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

William R. Ferrell, Elizabeth B. Kelso, John C. Lockhart, Elizabeth Burns, Robin Plevin, Iain B. McInnes

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

Abstract

Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.

Original language	English
Pages (from-to)	90-90
Number of pages	1
Journal	Rheumatology
Volume	50
Issue number	Supplement 3
DOIs	https://doi.org/10.1093/rheumatology/ker157
Publication status	Published - Apr 2011

Keywords

osteoarthritis
protase
arthritis research
therapeutic treatment

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10.1093/rheumatology/ker157

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title = "Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis",

abstract = "Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA. ",

keywords = "osteoarthritis, protase, arthritis research, therapeutic treatment",

author = "Ferrell, {William R.} and Kelso, {Elizabeth B.} and Lockhart, {John C.} and Elizabeth Burns and Robin Plevin and McInnes, {Iain B.}",

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AU - Ferrell, William R.

AU - Kelso, Elizabeth B.

AU - Lockhart, John C.

AU - Burns, Elizabeth

AU - Plevin, Robin

AU - McInnes, Iain B.

PY - 2011/4

Y1 - 2011/4

N2 - Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.

AB - Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.

KW - osteoarthritis

KW - protase

KW - arthritis research

KW - therapeutic treatment

U2 - 10.1093/rheumatology/ker157

DO - 10.1093/rheumatology/ker157

M3 - Conference Contribution

SN - 1462-0324

VL - 50

SP - 90

EP - 90

JO - Rheumatology

JF - Rheumatology

IS - Supplement 3

ER -

Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

Abstract

Keywords

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